Percorrer por autor "Oliveira, Ana I."
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- Antioxidant activity of Artemisia annua LPublication . Vieira, Rita; Pinho, Cláudia; Oliveira, Ana I.; Oliveira, Rita F.; Cruz, AgostinhoTea infusions of Artemisia annua are known for their prophylactic and therapeutic efficacy against malaria. However, recent studies have revealed that A. annua possess a variety of pharmacological activities such as antibacterial, cytotoxic and antioxidant.
- Azadirachta indica A. Juss. In Vivo Toxicity—An Updated ReviewPublication . Braga, Teresa M.; Rocha, Lídia; Chung, Tsz Yan; Ferraz Oliveira, Rita; Pinho, Cláudia; Oliveira, Ana I.; Morgado, Joaquim; Cruz, AgostinhoThe Neem tree, Azadirachta indica A. Juss., is known for its large spectrum of compounds with biological and pharmacological interest. These include, among others, activities that are anticancer, antibacterial, antiviral, and anti-inflammatory. Some neem compounds are also used as insecticides, herbicides, and/or antifeedants. The safety of these compounds is not always taken into consideration and few in vivo toxicity studies have been performed. The current study is a literature review of the latest in vivo toxicity of A. indica. It is divided in two major sections—aquatic animals toxicity and mammalian toxicity—each related to neem’s application as a pesticide or a potential new therapeutic drug, respectively.
- Comparison of antioxidant activity for Ginkgo biloba L. and Rosmarinus officinalis LPublication . Silva, Diana; França, Ana; Pinho, Cláudia; Oliveira, Ana I.; Oliveira, Rita F.; Cruz, AgostinhoNatural antioxidant products have gained popularity worldwide and are increasingly being used to treat various diseases. Leaves of Rosmarinus officinalis L. and Ginkgo biloba L. possess a variety of bioactivities, including antioxidant.
- Complexity of the therapeutic regimen in older adults with cancer: associated factorsPublication . Oliveira, Rita F.; Oliveira, Ana I.; Cruz. Agostinho; Ribeiro, Oscar; Afreixo, Vera; Pimentel, Francisco; Cruz, Agostinho; Ferraz Oliveira, Rita; Oliveira, Ana IsabelPopulation aging is a worldwide phenomenon and is often associated with multimorbidity and polypharmacy. Complex medication regimens are common among older adults and contribute to the occurrence of harmful health outcomes. Age is one of the main risk factors for cancer. This study aimed to determine and characterize the therapeutic complexity in older patients with cancer, and analyze the factors associated with high complexity and the impact of the oncological context. A cross-sectional study with patients aged ≥65 years with cancer was conducted in three hospitals in northern Portugal. Data collection was obtained using self-reports. The medication regimen complexity was assessed using the Medication Regimen Complexity Index (MRCI). Descriptive and association statistical analysis were performed. Logistic, linear, simple and multiple regression analysis were conducted, with and without automatic variable selection. A total of 552 patients were included (median age, 71; IQR, 68–76). The mean MRCI before the oncological context was 18.67 (SD 12.60) and 27.39 (SD 16.67) after the oncological context, presenting a statistically significant difference in the values obtained (p < 0.001). An elevated complexity was significantly associated with polypharmacy, chronic diseases and with the administration of high-risk medications (p < 0.05). High MRCI values showed a relationship with the occurrence of potential drug interactions (p < 0.001). There was no relationship with the existence of cardiac risk comorbidity. This study demonstrated the existence of high therapeutic complexity in older patients with cancer, suggesting the need for intervention to prevent medication-related problems in this vulnerable population.
- Phytochemical screening from Rosmarinus officinalis and Ginkgo biloba leaf extractsPublication . França, Ana; Silva, Diana; Oliveira, Ana I.; Oliveira, Rita F; Pinho, Cláudia; Cruz, AgostinhoCurrently, drug therapy with oral antidiabetic agents, is capable of inducing normoglycemia levels able to decrease the risk of complications associated with diabetes mellitus. However, it is also known that the various existing oral antidiabetic agents may trigger a large number of adverse events, either alone or in combination. Some of these tolerability and security issues related to the oral antidiabetic are reported by patients and can influence negatively or satisfaction with treatment or glycaemic control, or the therapeutic adherence and maintenance. It is therefore very important the role of patients in monitoring of adverse events related to the use of the oral antidiabetic drugs in order to optimize treatment and improve the quality of life of patients with type 2 diabetes (DM2).
- Urinary tract infections and dietary supplements: counselling in pharmacyPublication . Novais, Marta; Pinho, Cláudia; Oliveira, Ana I.; Ferraz Oliveira, Rita; Cruz, AgostinhoUrinary tract infections (UTIs) are some of the most common bacterial infections. Treatment usually involves antibiotics, and recurrence is a major concern. Therefore, identifying new and effective strategies, like the use of botanical dietary supplements, to control UTIs is a high priority. It is also important to provide health professionals with adequate knowledge related to the use of dietary supplements and other complementary and/or alternative medicines.