Browsing by Author "Natal Jorge, Renato"
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- Computational simulation of the cupula behavior in vestibular pathologies of the inner earPublication . Santos, Carla; Gentil, Fernanda; Parente, Marco; Areias, Bruno; Belinha, Jorge; Natal Jorge, RenatoVertigo is reported as one of the most common symptoms in the world, commonly related with vestibular disorders. It is considered the third most frequent complaint in medicine, transmitting a sense of inadequacy and insecurity, mainly in elders. The aim of this work is to contribute to a better understanding on how the vestibular system works, mainly during vestibular rehabilitation process. This knowledge will help in the development of new techniques that will facilitate a more efficient rehabilitation. Vestibular rehabilitation consists in a set of exercises, known as maneuvers, that can reduce and even eliminate the symptoms of dizziness and imbalance associated with a vestibular disorder.
- Using a meshless method to assess the effect of mechanical loading in angiogenesisPublication . Guerra, Ana; Belinha, Jorge; Natal Jorge, RenatoAlthough it is known that blood vessels can be found in mechanically active environments, less is known about the effect of mechanical stimulus in angiogenesis. Therefore, understanding how endothelial cells respond to a mechanical stimulus is essential to improve tissue vascularization and to promote wound healing and tissue engineering development. In this work, a meshless method is used to combine an elasticity formulation with a capillary growth algorithm. The final numerical model is capable to simulate the effect of compressive loading in angiogenesis, using three strain magnitudes (5, 10 and 30% strain). In this proposed model, the vascular endothelial growth factor gradient regulates the endothelial cell migration and the compressive loading affects the branching process. The numerical results showed that all the compressive loadings tested increased the vascular network length and the number of branches, being 5% strain magnitude the most effective one. The capillary network obtained resembles the one presented in experimental assays and the obtained numerical results coincided to the experimental ones. Nevertheless, this study possesses some limitations since the viscoelastic properties of the tissue, the dynamic loading effect and the effect of the time variable were not considered. In the future, the combination of computational and experimental studies will be very useful to understand and to define which are the mechanical cues that promote angiogenesis, allowing to improve tissue vascularization and, consequently, the wound healing process.