Browsing by Author "Moreira, Daniel"
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- mRPL+: A mobility management framework in RPL/6LoWPANPublication . Fotouhi, Hossein; Moreira, Daniel; Alves, Mário; Yomsi, Patrick YomsiThe next generation Internet (also known as Internet-of-Things – IoT), will ubiquitously integrate trillions of computing devices of all kinds, shapes and sizes. For this ubiquity to materialize, a key aspect will certainly be interoperability, the capability of different technologies (e.g. different communication protocols at both horizontal and vertical levels, different hardware platforms, different operating systems, fixed and mobile nodes, etc) to talk to and understand each other. A major enabler for this interoperability is the use of standard and commercial-off-the-shelf technologies (e.g. communication protocols, hardware platforms, operating systems). As IPv6 has become the de-facto communication technology for the Internet, 6LoWPAN has recently started paving the way for extending the Internet to low-power low-cost wireless devices. However, while mobility support will be a requirement (or at least beneficial) in many applications contexts, the support of mobile nodes in the default 6loWPAN/RPL protocol leads to excessive packet loss and delays. In this work, we show that interoperability between fixed and mobile nodes can be successfully achieved through the use of appropriate hand-off and topology management techniques. We propose a mobility management framework (dubbed mRPL+) unifying two hand-off models: (1) hard hand-off, where a mobile node has to break a link before finding a new link, and (2) soft hand-off , where a mobile node selects the new link before disconnecting from the current one. Importantly, mRPL+ is integrated in the 6LoWPAN/RPL stack in a backward compatible manner. Simulation results indicate that in a network with mobile nodes, packet delivery ratio with mRPL+ is nearly 100%, where RPL achieves 80% in best-case. Hand-off process has a disconnected period of few milliseconds (hand-off delay = 4 ms), while RPL experiences few seconds of disconnection during node’s mobility (3−10 s).
- mRPL: Boosting mobility in the Internet of ThingsPublication . Fotouhi, Hossein; Moreira, Daniel; Alves, MárioThe 6loWPAN (the light version of IPv6) and RPL (routing protocol for low-power and lossy links) protocols have become de facto standards for the Internet of Things (IoT). In this paper, we show that the two native algorithms that handle changes in network topology – the Trickle and Neighbor Discovery algorithms – behave in a reactive fashion and thus are not prepared for the dynamics inherent to nodes mobility. Many emerging and upcoming IoT application scenarios are expected to impose real-time and reliable mobile data collection, which are not compatible with the long message latency, high packet loss and high overhead exhibited by the native RPL/6loWPAN protocols. To solve this problem, we integrate a proactive hand-off mechanism (dubbed smart-HOP) within RPL, which is very simple, effective and backward compatible with the standard protocol. We show that this add-on halves the packet loss and reduces the hand-off delay dramatically to one tenth of a second, upon nodes’ mobility, with a sub-percent overhead. The smart-HOP algorithm has been implemented and integrated in the Contiki 6LoWPAN/RPL stack (source-code available on-line mrpl: smart-hop within rpl, 2014) and validated through extensive simulation and experimentation.
- Structure–Activity Relationship of Piplartine and Synthetic Analogues against Schistosoma mansoni and Cytotoxicity to Mammalian CellsPublication . Campelo, Yuri; Ombredane, Alicia; Vasconcelos, Andreanne; Albuquerque, Lucas; Moreira, Daniel; Plácido, Alexandra; Rocha, Jefferson; Fokoue, Harold Hilarion; Yamaguchi, Lydia; Mafud, Ana; Mascarenhas, Yvonne; Delerue-Matos, Cristina; Borges, Tatiana; Joanitti, Graziella; Arcanjo, Daniel; Kato, Massuo; Kuckelhaus, Selma; Silva, Marcos; Moraes, Josué; Leite, JoséSchistosomiasis, caused by helminth flatworms of the genus Schistosoma, is an infectious disease mainly associated with poverty that affects millions of people worldwide. Since treatment for this disease relies only on the use of praziquantel, there is an urgent need to identify new antischistosomal drugs. Piplartine is an amide alkaloid found in several Piper species (Piperaceae) that exhibits antischistosomal properties. The aim of this study was to evaluate the structure–function relationship between piplartine and its five synthetic analogues (19A, 1G, 1M, 14B and 6B) against Schistosoma mansoni adult worms, as well as its cytotoxicity to mammalian cells using murine fibroblast (NIH-3T3) and BALB/cN macrophage (J774A.1) cell lines. In addition, density functional theory calculations and in silico analysis were used to predict physicochemical and toxicity parameters. Bioassays revealed that piplartine is active against S. mansoni at low concentrations (5⁻10 µM), but its analogues did not. In contrast, based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry assays, piplartine exhibited toxicity in mammalian cells at 785 µM, while its analogues 19A and 6B did not reduce cell viability at the same concentrations. This study demonstrated that piplartine analogues showed less activity against S. mansoni but presented lower toxicity than piplartine.