Browsing by Author "Martins, Sara"
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- Adverse reactions mediated by radiopharmaceuticals for palliative treatment of bone metastases: asystematic review of literaturePublication . Pinho, Cláudia; Martins, Sara; Jesus, Ângelo; Suárez, Ana MartínBone metastases are one of the most frequent complications of advanced cancers and one of the therapies used for the palliative treatment of pain associated with them is radiopharmaceutical therapy. Like any other drug, radiopharmaceuticalscan cause adverse reactions (AR). Therefore, a global and up-to-date view of AR related to radiopharmaceuticals is essential, to allow the detection, understanding and management of them by health professionals and the patient. Reviewthe results and conclusions of studies on the use of RF in the palliative treatment of pain associated with bone metastases, particularly, Strontium-89 (89Sr), Samarium-153 (153Sm), Rhenium-186 (186Re) and Rhenium-188 (188Re). A systematic literature review was conducted according to PRISMA statement, using the databases MEDLINE and EBSCO. After the selection process, 20 articles were included. The main AR reported are flare responsesand hematologic toxicity. All the studies recovered show that these drugs can provide safe, symptomatic relief from painfulosseous metastases and, in most cases, the hematological toxicity was reversible, even in elderly and severely ill patients. There is also evidence of secondary outputs for health and quality of life.Conclusions:Pain is among the most common and distressing symptoms encountered by patients with advanced cancer. The challenge of pain palliation is to achieve effective relief with minimal AR. The studies analyzed presented very similar results regarding pain relief after treatment, decrease in analgesic consumption, AR at the time of administration, hematologic toxicity and disease progression after treatment. The use of RF for pain palliation seems to be safe and an alternative to existing treatments, however more studies are need no access safety and toxicity. Pharmacovigilance of radiopharmaceuticsl is imperative so we can safely study the possible adverse effects of such drugs.
- Adverse reactions mediated by Strontium-89, Samarium-153, Rhenium-186 and Rhenium-188: A Systematic Review of LiteraturePublication . Pinho, Cláudia; Martins, Sara; Jesus, Ângelo; Suárez, Ana MartínOne of the therapies used for the palliative treatment of pain associated with bone metastases is radiopharmaceutical therapy. Radiopharmaceuticals can cause adverse reactions, and, therefore, the aim is to systematize the results and conclusions of studies on the use of the radiopharmaceuticals 89Sr, 153Sm, 186Re and 188Re in the palliative treatment of pain associated with bone metastases. A systematic literature review was conducted according to PRISMA statement, using the databases MEDLINE and EBSCO. After the selection process, 20 articles were included. The studies showed that the 4 radiopharmaceuticals analysed presented very similar results regarding pain relief after treatment, decrease in analgesic consumption, side effects at the time of administration, hematologic toxicity and disease progression after treatment. Concluding, the use of radiopharmaceuticals for pain palliation seems to be safe and an alternative to existing treatments.
- Disfagia no idoso e suas implicações na administração de formas farmacêuticas sólidas orais [artigo]Publication . Martins, Sara; Jesus, ÂngeloA disfagia define-se como a dificuldade na deglutição, que afeta a ingestão de alimentos, mas também medicamentos, sendo mais prevalente em idades avançadas. Para contornar esta dificuldade, os idosos recorrem à alteração da forma física do medicamento, resultando em consequências para si e para a terapêutica, como o aparecimento de reações adversas e toxicidade. Este trabalho procurou identificar as principais dificuldades na administração de formas farmacêuticas sólidas orais, em indivíduos com mais de 60 anos, e as suas implicações na adesão à terapêutica. Desenvolveu-se um estudo exploratório por questionário, aplicado por meio de entrevista, entre os meses de dezembro de 2016 e maio de 2017. O estudo investigou 102 indivíduos com mais de 60 anos. Cerca de metade dos entrevistados apresentam difi culdades em deglutir medicamentos com forma farmacêutica sólida oral, sendo que o tamanho é a característica que mais afeta essa dificuldade, levando frequentemente à alteração da forma física do medicamento e tendo implicações na adesão à terapêutica.
- Pharmacovigilance of radiopharmaceuticals: Challenges and opportunitiesPublication . Martins, Sara; Jesus, Ângelo; Martín-Suárez, AnaRadiopharmaceuticals are unique in that they contain radioactive isotopes which emit radiation for diagnostic or therapeutic purposes.1 They are also used in very small dosages when compared to conventional drugs and the frequency of administrating radiopharmaceuticals in an individual during is lifetime is also very low. Nevertheless due to their specific nature, radiopharmaceuticals require careful monitoring and surveillance to detect and manage any potential adverse effects or safety concerns.2 Pharmacists, radiations technologists, physicians and other hospital staff play a crucial role in ensuring the safe handling, administration, and monitoring of these specialized drugs. Their joint involvement in pharmacovigilance is essential for maintaining patient safety and optimizing the use of radiopharmaceuticals.