Browsing by Author "Marques, M. P. M."
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- Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studiesPublication . Vojtek, Martin; Pinto, Edgar; Gonçalves-Monteiro, Salomé; Almeida, Agostinho; Marques, M. P. M.; Mota-File, Hélder; Ferreira, Isabel M. P. L. V. O.; Diniz, CarmenPalladium-(Pd)-based drugs are emerging as alternatives to platinum (Pt) anticancer chemotherapeutics, which increases the need for efficient and suitable procedures of Pd analysis in reduced amounts of pre-clinical animal samples. Herein, an ICP-MS (inductively coupled plasma-mass spectrometry) method was developed and validated for simple and fast analysis of Pd/Pt-based drugs in 11 distinct biological matrices (adipose tissue, muscle, liver, kidney, spleen, testis, heart, lungs, brain, blood and serum).