Repository logo

Browsing by Author "Luis, C."

Now showing 1 - 2 of 2
  • Galectin-3: a biomarker of metabolic progression of type 2 diabetes?
    Publication . Luis, C.; Soares, R.; Baylina, Pilar; Fernandes, R.
    According to the International Diabetes Federation, Diabetes mellitus type 2 (DM2) has affected more than 425 million people in 2017 worldwide]. Not only is it a disease responsible for more than 4 million deaths, but also a trigger for other non communicable diseases and a huge burden on national health systems. The most important clinical manifestation of T2DM is hyperglycemia and monitoring of blood glucose levels remains the only method of screening. However, when glucose levels are high, the disease is already in place. The large investment in DM2 research allowed the identification of biomarkers that could be used to describe the progression of diabetes and some were described as having a predictive potential value to differentiate between progressors / non-progressors. One of the biomarkers described is Galectin-3 (Gal3). Previous studies of our group have already demonstrated a correlation of Gal3 between diabetic and non-diabetic animals.
    2019-04Conference object Open access Show more
  • Glycated Albumin: A new biomarker for monitoring metabolic progression of diabetes
    Publication . Ribeiro, A. R.; Luis, C.; Baylina, Pilar; Fernandes, R.
    One of the consequences of the metabolic progression of diabetes is kidney disease, being also a main cause of diabetes related morbidity and mortality. Therefore, earlier adoption of methods to estimate chronic kidney disease risks along with a more accurate glycemic index for patients with type 2 diabetes mellitus is highly desirable. One of the widely used tubular injury markers is N-acetyl-β-D-glucosaminidase (NAG), a lysosomal enzyme of renal proximal tubular epithelial cells. One study demonstrated that the association between glycated albumin (GA) and uNAG excretion and observed that GA was significantly associated with uNAG excretion independent of other confounding factors. Consequently, this study suggest that GA can be a strong independent predictor of early renal tubular damage, beyond its role as a surrogate marker of glucose control (Huh et al., 2018).
    2019-04Conference object Open access Show more