Browsing by Author "Henriques, Vanessa Mendes"
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- Diabetic rats lose A2A receptor-mediated facilitation of ileal myenteric cholinergic neurotransmissionPublication . Monteiro, Salomé Gonçalves; Cardoso, Maria Teresa Magalhães; Ferreirinha, Fátima; Henriques, Vanessa Mendes; Sá, Paulo Correia de; Araújo, Margarida DuarteEnteric dysmotility is a long-term complication of Diabetes mellitus that causes significant discomfort in 76% of diabetic outpatients. Knowing that purines may be involved in synaptic transmission modifications in the CNS of diabetic rats, we decided to investigate if purinergic dysfunction could also play a role in diabetic enteric neuropathy in rats.
- Morphofunctional characterization of the ileum in a type 1 diabetes rat model 7Publication . Henriques, Vanessa Mendes; Monteiro, Salomé Gonçalves; Vieira, Filipa Quintela; Sá, Paulo Correia de; Araújo, Margarida DuarteDiabetes mellitus (DM) is a metabolic disorder that affects 1 in 12 people with high mortality and morbidity. Knowing that about 76% of diabetic patients have gastrointestinal complications, we decided to characterize morphologically and functionally the ileum of a rat (Rattus norvegicus, Wistar) model that mimics type 1 DM. Diabetes was chemically induced by a single intraperitoneal injection of streptozotocin (STZ, 55mg/kg). All animals were used 14 days after injection with saline (CTRL-group) or STZ (STZ-group).