Browsing by Author "Guedes, Marta"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
- Combination therapy with CD147‐targeted nanoparticles carrying phenformin decreases lung cancer growthPublication . Pereira-Nunes, Andreia; Ferreira, Helena; Abreu, Sara; Guedes, Marta; Neves, Nuno M.; Baltazar, Fátima; Granja, Sara; Granja, SaraLung cancer is one of the most fatal cancers worldwide. Resistance to conventional therapies remains a hindrance to patient treatment. Therefore, the development of more effective anti-cancer therapeutic strategies is imperative. Solid tumors exhibit a hyperglycolytic phenotype, leading to enhanced lactate production; and, consequently, its extrusion to the tumor microenvironment. Previous data reveals that inhibition of CD147, the chaperone of lactate transporters (MCTs), decreases lactate export in lung cancer cells and sensitizes them to phenformin, leading to a drastic decrease in cell growth. In this study, the development of anti-CD147 targeted liposomes (LUVs) carrying phenformin is envisioned, and their efficacy is evaluated to eliminate lung cancer cells. Herein, the therapeutic effect of free phenformin and anti-CD147 antibody, as well as the efficacy of anti-CD147 LUVs carrying phenformin on A549, H292, and PC-9 cell growth, metabolism, and invasion, are evaluated. Data reveals that phenformin decreases 2D and 3D-cancer cell growth and that the anti-CD147 antibody reduces cell invasion. Importantly, anti-CD147 LUVs carrying phenformin are internalized by cancer cells and impaired lung cancer cell growth in vitro and in vivo. Overall, these results provide evidence for the effectiveness of anti-CD147 LUVs carrying phenformin in compromising lung cancer cell aggressiveness.
- Marketing's impact on sustainable tourism: an empirical study of hotel units in the Northern Region of PortugalPublication . Liberato, Dália; Ferreira, Fernanda A.; Guedes, Marta; Costa, Elga; Liberato, PedroSustainable tourism emerges as a response to mass tourism, caused by the intensification of travel. As a result of Sustainable Tourism, the practice of Responsible Tourism and Conscious Tourism emerges, leading to behaviors of greater environmental, cultural, and social sustainability at the destination, but also to an increasing environmental concern. The hospitality sector, government agencies, trade associations and tourism service providers in each country play a pivotal role in increasing environmental awareness/education among local communities and visitors at the destination. The main objective of this research is to understand the importance of Marketing in Sustainable Tourism, applied to hotel units in the northern region of Portugal. As specific objectives, the research aims to: Identify the marketing strategies adopted by the hotel units that lead to greater involvement of stakeholders (tourists, employees, stakeholders and local community), Identify the marketing strategies adopted by the hotel units, valued by the guests, before, during and after the tourist experience and find out how Marketing in Sustainable Tourism contributes to the dynamization of the region and improvement of the destination experience. In the development of this study, a qualitative methodology was selected, consisting of an exploratory study, based on semi-structured interviews. The sample consists of directors and/or managers of hotel units awarded with the “Green Key” certification, in 2022, in the northern region of Portugal. Furthermore, some partner entities that assist in the certification of these enterprises were also included, namely ABAE and consulting companies in the Sustainable Tourism sector. From an analytical point of view, it provides interesting results for the northern region of Portugal, where a continuous growth toward its sustainable development is expected, with an increasing number of certified tourist accommodations and their contribution to the distribution of economic wealth in the region, dynamization and promotion, as well as the responsible engagement of tourists with residents and increasing awareness of these indicators.