Percorrer por autor "Fernandes, Maria Margarida Nogueira"
A mostrar 1 - 1 de 1
Resultados por página
Opções de ordenação
- Bioadhesive hydrogels based on collagen for bone regenerationPublication . Fernandes, Maria Margarida Nogueira; Alves, Natália; Peixoto, Daniela; Vieira, MónicaBone exhibits a unique characteristic of self-regeneration in response to a fracture; however, when the fracture is extensive, bone grafts may be necessary. Since this option presents several limitations and risks for the patient, tissue engineering emerges as a promising alternative, offering solutions for treating these fractures by creating devices or materials for bone regeneration. Hydrogels represent a promising alternative for bone regeneration, as they possess a structure similar to the extracellular matrix (ECM), are biocompatible, and enable the incorporation of molecules that stimulate osteogenesis. Collagen is a primary component of the extracellular matrix (ECM) and the primary component of bone, making it an ideal material for developing new scaffolds for bone applications. When modified with catechol groups, the hydrogels exhibit enhanced adhesive capacity, a desirable characteristic for regenerative applications. Gallium-doped bioglass nanoparticles are promising for bone regeneration because they stimulate osteogenesis and have antibacterial properties. In this dissertation, composite hydrogels of collagen modified with catechol groups and gallium-doped bioglass nanoparticles were developed. It was found that these hydrogels possess high adhesive capacity, bioactivity, antibacterial properties, and cytocompatibility, thereby having potential applications in bone regeneration.