Browsing by Author "Fernandes, J."
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- Da planificação à ação: uma experiência de sucesso no Mestrado de Higiene e SegurançaPublication . Dores, Artemisa Rocha; Fernandes, J.; Cavadas, I.; Filipe, J.; Santos, J.; Nunes, M.A unidade curricular de Educação e Gestão da Formação decorre no âmbito do 1º ano do mestrado de Educação e Gestão da Formação, da Escola Superior de Tecnologia da Saúde do Porto – P.PORTO. Alguns dos seus objetivos são: relacionar a saúde com diferentes contextos de desenvolvimento; refletir acerca da importância da educação em saúde, segurança e ambiente (ESSA); identificar eixos de atuação prioritária em matéria da educação para a segurança, demonstrar conhecimentos nas áreas de desenho/ implementação/avaliação de projetos de ESSA; desenvolver ações de formação/sensibilização nas áreas e aplicar competências pedagógicas.
- Development and validation of a tool to evaluate resilience performance in metalworking industryPublication . Fernandes, J.; Ferreira, C.; Rubio-Romero, J.C.; Rodrigues, MatildeFor several organizations, occupational risk management is focused on risk assessment, accident investigation and analysis, and implementation of control measures. Investigation and analysis of accidents is often carried out taking into account causation models, with the objective of identifying the causes and determining effective corrective measures to improve both current practices and risk control systems. This behavior of the organizations fits in the traditional perspective of safety, realized as the absence of unwanted events
- Protective effect of C. sativa leaf extract against UV mediated-DNA damage in a human keratinocyte cell linePublication . Almeida, Isabel F.; Pinto, A.S.; Monteiro, C.; Monteiro, H.; Belo, L.; Fernandes, J.; Bento, A.R.; Duarte, T.L.; Garrido, J.; Bahia, Maria Fernanda; Lobo, J.M. Sousa; Costa, P.C.Toxic effects of ultraviolet (UV) radiation on skin include protein and lipid oxidation, and DNA damage. The latter is known to play a major role in photocarcinogenesis and photoaging. Many plant extracts and natural compounds are emerging as photoprotective agents. Castanea sativa leaf extract is able to scavenge several reactive species that have been associated to UV-induced oxidative stress. The aim of this work was to analyze the protective effect of C. sativa extract (ECS) at different concentrations (0.001, 0.01, 0.05 and 0.1 μg/mL) against the UV mediated-DNA damage in a human keratinocyte cell line (HaCaT). For this purpose, the cytokinesis-block micronucleus assay was used. Elucidation of the protective mechanism was undertaken regarding UV absorption, influence on 1O2 mediated effects or NRF2 activation. ECS presented a concentration-dependent protective effect against UV-mediated DNA damage in HaCaT cells. The maximum protection afforded (66.4%) was achieved with the concentration of 0.1 μg/mL. This effect was found to be related to a direct antioxidant effect (involving 1O2) rather than activation of the endogenous antioxidant response coordinated by NRF2. Electrochemical studies showed that the good antioxidant capacity of the ECS can be ascribed to the presence of a pool of different phenolic antioxidants. No genotoxic or phototoxic effects were observed after incubation of HaCaT cells with ECS (up to 0.1 μg/mL). Taken together these results reinforce the putative application of this plant extract in the prevention/minimization of UV deleterious effects on skin.
- QFD as a tool to improve negotiation process, product quality, and market success, in an automotive industry battery components supplierPublication . Fonseca, Luís Miguel Ciravegna; Fernandes, J.; Delgado, C.The automotive industry faces major megatrends such as climate change and emissions control, digital transformation, and increased customer power, resulting in more intensive competition, and higher sophisticated vehicles. The application of QFD (Quality Function Deployment) can be particularly valuable to link customer expectations with the technical characteristics of the product. In the case of products, such as batteries for electric vehicles, where technology is not yet mature, and the technical requirements (e.g., autonomy) are continuously more demanding, this is particularly relevant. The QFD customer-oriented product development technique is applied to a cover of a battery pack, to improve the negotiation process with the car manufacturer, the automotive industry battery components supplier company and its suppliers, to ensure market success once the product is released. The application of the HoQ revealed that Product Design and Tolerancing are the main technical requirements with the most impact over the battery cover development, followed the Leakage ratio. This research confirms that the voice of the customer could be quite generic, and it is critical that these requirements are translated into engineering requirements, which, in turn, can be translated into items that can be measured quantitatively and actionable within the company. The application of the affinity diagram was found to be quite valuable to address the significant amount of subjective information, and it is also relevant that OEMs have a desire to standardize the electric vehicle platforms at least on fewer and general sizes, hinting the need for more collaborative team approaches.