Browsing by Author "Botelho, Elisa"
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- 99mTc-MAA for Lung Perfusion Scintigraphy: Impact of Counting Method on the Effective Number of Particles Administered and Particle Aggregation Over TimePublication . Costa, Pedro; Cunha, Lídia; Soares, Sofia; Mendes, Ângela; Queiroz, Ana; Nunes, Amélia; Ferreira, Elisabete; Botelho, Elisa; Sousa, Maria C.; Castro, Rosa; Pires, Laucena; João, M. Faria; Metello, Luís F.: 99mTc-MAA (macroaggregates of albumin) is the selected radiopharmaceutical for the Lung Perfusion Scintigraphy. It is retained in lung capillaries by mechanical blockage resulting in local microembolization. Care should be taken concerning not only particle size but also the number of particles administered to patients, particularly those who present with special conditions (pulmonary hypertension, shunt or lung transplant). European Pharmacopoeia only requires the assessment of particle size. This work aims to characterize particle size and particle aggregation of two commercial brands of MAA kits and to compare particle counting methods
- 99mTc-MAA for Lung Perfusion Scintigraphy: Impact of Counting Method on the Effective Number of Particles Administered and Particle Aggregation Over TimePublication . Costa, Pedro; Cunha, Lídia; Soares, Sofia; Mendes, Ângela; Queiroz, A. Isabel; Nunes, Amélia; Ferreira, Elisabete; Botelho, Elisa; Sousa, Conceição; Castro, Rosa; Pires, Laucena; João, M. Faria; Metello, Luís F.Introduction: 99mTc-MAA (macroaggregates of albumin) is the selected radiopharmaceutical for the Lung Perfusion Scintigraphy. It is retained in lung capillaries by mechanical blockage resulting in local microembolization. Care should be taken concerning not only particle size butalso the number of particles administered to patients, particularly those who present with special conditions (pulmonary hypertension, shunt or lung transplant). European Pharmacopoeia only requires the assessment of particle size. This work aims to characterize particle size and particle aggregation of two commercial brands of MAA kits and to compare particle counting methods.
- Large-scale Centralized Radiopharmacies: Is There Any Reason for Concern? An Insight into 99mTc-radiopharmaceuticals Adsorption and StabilityPublication . Costa, Pedro; Cunha, Lídia; Oliveira, Tânia; Rebelo, Ana; Nunes, Amélia; Milhões, Marta; Botelho, ElisaWorldwide, regulatory issues related to the field of radiopharmacy are switching and turning each day more rigid. Due to these legal constraints and all the related economical consequences, the concept of large-scale radiopharmacies, that label and distribute radiopharmaceuticals in a ready-to-use form, disseminate widely and seem more and more attractive, even in usually less receptive countries. In such a context, issues as the appropriate choice for recipient/methodology (vial or syringe? Multi- or Monodoses?) as well as the adoption of distinct behaviors should be considered relevant. Aim: It is aimed to disseminate the results obtained on a large study performed to evaluate whether there is any correlation between factors as syringe volume, residence time and type of radiopharmaceutical with adsorbed fraction and stability