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Authors
Advisor(s)
Abstract(s)
Allied to an epidemiological study of population of the Senology Unit of Braga’s
Hospital that have been diagnosed with malignant breast cancer, we describe the
progression in time of repeated measurements of tumor marker Carcinoembryonic
antigen (CEA). Our main purpose is to describe the progression of this tumor marker
as a function of possible risk factors and, hence, to understand how these risk factors
influences that progression. The response variable, values of CEA, was analyzed
making use of longitudinal models, testing for different correlation structures. The
same covariates used in a previous survival analysis were considered in the longitudinal
model. The reference time used was time from diagnose until death from breast cancer.
For diagnostic of the models fitted we have used empirical and theoretical variograms.
To evaluate the fixed term of the longitudinal model we have tested for a changing
point on the effect of time on the tumor marker progression. A longitudinal model
was also fitted only to the subset of patients that died from breast cancer, using the
reference time as time from date of death until blood test.
Description
Keywords
breast cancer carcinoembryonic antigen longitudinal models
Citation
Borges, A., Sousa, I., Castro, L., “Longitudinal Analysis of Tumor Marker CEA of Breast Cancer patients from Braga's Hospital”, REVSTAT 13(1) (2015), 63–78