Repository logo
 
Publication

Characterization of carbon dots and its impact in a breast cancer cell line

2023Conference object Restricted access
Simple item page
dc.contributor.authorMagalhães, Sofia
dc.contributor.authorLuís, Carla
dc.contributor.authorFraga, Hugo
dc.contributor.authorDuarte, Abel J.
dc.date.accessioned2024-05-03T13:22:09Z
dc.date.available2024-05-03T13:22:09Z
dc.date.issued2023
dc.descriptionThis work was supported by DGES (Direção Geral de Ensino Superior) by a scholarship granted to Sofia Magalhães (number 1581670).pt_PT
dc.description.abstractCarbon dots (CD) have emerged as a novel promising alternative to metal-based nanoparticles. These fluorescence carbon materials have been the subject of research since 2004 and exhibit excellent chemical and physical properties such as hydrophilicity, good biocompatibility and reduced toxicity, which allows a good interaction with biological systems. Taking this in consideration it is not surprising that CD have been introduced for the study/therapeutics of breast cancer , especially, in drug delivery system, bioimaging, biosensor, microbial therapy, photodynamic and photothermal therapy. Breast cancer is the most prevalent cancer with a high morbidity rate in the female population worldwide. In this study, we considered the use of fructose derived CD for breast cancer therapy. CD were produced from D-fructose via microwave irradiation by the bottom-up method. Following purification, particles were characterized using TEM, FTIR, DLS and fluorescence microscopy. As expected, fructose derived CD consist of carbon, oxygen and hydrogen. As characteristic of CD, they are fluorescent with an absorption maximum at 360 nm that when irradiated at 360 nm have an emission maximum at 520 and a broad emission band (maximum 520 nm). In what concern cell-based assays, our results using breast cancer cell line BT474 and MCF-10A breast epithelial cells show CD are able to penetrate the cell membrane and display cytotoxicity towards tumor cell lines. In still preliminary results, it appears that they have reduced toxicity versus non tumor cell line, suggesting that they can be used as anti-tumoral agents for therapeutic purposes.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.citationMagalhães, S., Luís, C., Fraga, H., & Duarte, A. (2023, May 10-12). Characterization of carbon dots and its impact in a breast cancer cell line [Poster]. IJUP - Investigação Jovem da Universidade do Porto, 16ª ed., Porto, Portugalpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/25461
dc.language.isoengpt_PT
dc.subjectCarbon dotspt_PT
dc.subjectNanoparticlespt_PT
dc.subjectBreast cancerpt_PT
dc.subjectCell culturept_PT
dc.titleCharacterization of carbon dots and its impact in a breast cancer cell linept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePorto, Portugalpt_PT
oaire.citation.titleIJUP 2023 - Investigação Jovem da Universidade do Porto, 16ª ed., Maio 10-12pt_PT
person.familyNameDuarte
person.givenNameAbel J.
person.identifier.ciencia-idD713-A799-54D3
person.identifier.orcid0000-0003-0218-1952
person.identifier.ridD-8312-2013
person.identifier.scopus-author-id7102602124
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication8c571d8e-cde8-4a7a-8044-5444e01f9bc0
relation.isAuthorOfPublication.latestForDiscovery8c571d8e-cde8-4a7a-8044-5444e01f9bc0

Files

Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
55_Characterization of carbon dots and its impact in a breast cancer cell line.pdf
Size:
2.21 MB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
55_IJUP23_Livro-de-Resumos_p840_abstrct.pdf
Size:
1.13 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ISEP – CIETI – Comunicações em eventos científicos