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Harmful effects of metal(loid) oxide nanoparticles

2021Journal article Open access
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dc.contributor.authorSoares, Eduardo V.
dc.contributor.authorSoares, HMVM
dc.date.accessioned2022-03-23T17:00:03Z
dc.date.available2022-03-23T17:00:03Z
dc.date.issued2021
dc.description.abstractThe incorporation of nanomaterials (NMs), including metal(loid) oxide (MOx) nanoparticles (NPs), in the most diversified consumer products, has grown enormously in recent decades. Consequently, the contact between humans and these materials increased, as well as their presence in the environment. This fact has raised concerns and uncertainties about the possible risks of NMs to human health and the adverse effects on the environment. These concerns underline the need and importance of assessing its nanosecurity. The present review focuses on the main mechanisms underlying the MOx NPs toxicity, illustrated with different biological models: release of toxic ions, cellular uptake of NPs, oxidative stress, shading effect on photosynthetic microorganisms, physical restrain and damage of cell wall. Additionally, the biological models used to evaluate the potential hazardous of nanomaterials are briefly presented, with particular emphasis on the yeast Saccharomyces cerevisiae, as an alternative model in nanotoxicology. An overview containing recent scientific advances on cellular responses (toxic symptoms exhibited by yeasts) resulting from the interaction with MOx NPs (inhibition of cell proliferation, cell wall damage, alteration of function and morphology of organelles, presence of oxidative stress bio-indicators, gene expression changes, genotoxicity and cell dead) is critically presented. The elucidation of the toxic modes of action of MOx NPs in yeast cells can be very useful in providing additional clues about the impact of NPs on the physiology and metabolism of the eukaryotic cell. Current and future trends of MOx NPs toxicity, regarding their possible impacts on the environment and human health, are discussed.pt_PT
dc.description.sponsorshipThis work was supported by National funds through FCT - Foundation for Science and Technology under the scope of the projects UIDB/50006/2020, UID/BIO/04469/2020 unit and BioTecNorte opera- tion (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Nortept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSoares, Eduardo V.; Soares, Helena M. V. M., Harmful effects of metal(loid) oxide nanoparticles. Applied Microbiology and Biotechnology, 105, 1379-1394, 2021. DOI: 10.1007/s00253-021-11124-1pt_PT
dc.identifier.doi10.1007/s00253-021-11124-1pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/20301
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationUID/BIO/04469/2020pt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00253-021-11124-1pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAquatic organismspt_PT
dc.subjectHazard/risk assessmentpt_PT
dc.subjectMetal(loid) oxide nanoparticlespt_PT
dc.subjectNanosafetypt_PT
dc.subjectToxic modes of actionpt_PT
dc.subjectYeastpt_PT
dc.titleHarmful effects of metal(loid) oxide nanoparticlespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.citation.endPage1394pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage1379pt_PT
oaire.citation.titleApplied Microbiology and Biotechnologypt_PT
oaire.citation.volume105pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSoares
person.familyNameSoares
person.givenNameEduardo
person.givenNameHelena
person.identifier93637
person.identifierR-000-5VJ
person.identifier.ciencia-idD612-0D0E-4984
person.identifier.ciencia-id9217-AB59-AD85
person.identifier.orcid0000-0003-2280-5291
person.identifier.orcid0000-0002-5768-9182
person.identifier.ridO-5908-2015
person.identifier.ridD-5343-2013
person.identifier.scopus-author-id7102060173
person.identifier.scopus-author-id7006226822
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication1ab1f0f1-dcd6-4d6c-9592-ab5ee491586a
relation.isAuthorOfPublication.latestForDiscoveryb3ebdee1-84fa-4183-a1d8-c3cdcaaef219
relation.isProjectOfPublicationfc4a587f-c16e-4777-9549-2da7a1cf7d0e
relation.isProjectOfPublication.latestForDiscoveryfc4a587f-c16e-4777-9549-2da7a1cf7d0e

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