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Melanoma in the Eyes of Mechanobiology

2020Journal article Open access
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dc.contributor.authorBrás, M. Manuela
dc.contributor.authorRadmacher, Manfred
dc.contributor.authorSousa, Susana R.
dc.contributor.authorGranja, Pedro L.
dc.date.accessioned2022-01-13T15:45:31Z
dc.date.available2022-01-13T15:45:31Z
dc.date.issued2020
dc.description.abstractSkin is the largest organ of the human body with several important functions that can be impaired by injury, genetic or chronic diseases. Among all skin diseases, melanoma is one of the most severe, which can lead to death, due to metastization. Mechanotransduction has a crucial role for motility, invasion, adhesion and metastization processes, since it deals with the response of cells to physical forces. Signaling pathways are important to understand how physical cues produced or mediated by the Extracellular Matrix (ECM), affect healthy and tumor cells. During these processes, several molecules in the nucleus and cytoplasm are activated. Melanocytes, keratinocytes, fibroblasts and the ECM, play a crucial role in melanoma formation. This manuscript will address the synergy among melanocytes, keratinocytes, fibroblasts cells and the ECM considering their mechanical contribution and relevance in this disease. Mechanical properties of melanoma cells can also be influenced by pigmentation, which can be associated with changes in stiffness. Mechanical changes can be related with the adhesion, migration, or invasiveness potential of melanoma cells promoting a high metastization capacity of this cancer. Mechanosensing, mechanotransduction, and mechanoresponse will be highlighted with respect to the motility, invasion, adhesion and metastization in melanoma cancer.pt_PT
dc.description.sponsorshipThe authors acknowledge to Ana Silva (ana@anasilvaillustrations.com) for expert assistance with graphical design, and to Portuguese funds – FCT UID/BIM/04293/2019.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fcell.2020.00054pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/19464
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationInstitute for Research and Innovation in Health Sciences
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fcell.2020.00054/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectMelanomapt_PT
dc.subjectMEchanobiologypt_PT
dc.subjectMelanocytespt_PT
dc.subjectKeratinocytespt_PT
dc.subjectInvasionpt_PT
dc.subjectAdhesionpt_PT
dc.subjectMigrationpt_PT
dc.subjectMetastizationpt_PT
dc.titleMelanoma in the Eyes of Mechanobiologypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleInstitute for Research and Innovation in Health Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIM%2F04293%2F2019/PT
oaire.citation.titleFrontiers in Cell and Developmental Biologypt_PT
oaire.citation.volume8pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameR. Sousa
person.givenNameSusana
person.identifier820351
person.identifier.ciencia-id2D13-F15F-D519
person.identifier.orcid0000-0001-8018-4310
person.identifier.ridD-5356-2013
person.identifier.scopus-author-id10045389000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication13159acc-5117-4c06-9ee1-02820b9b6218
relation.isAuthorOfPublication.latestForDiscovery13159acc-5117-4c06-9ee1-02820b9b6218
relation.isProjectOfPublicationbe9e472b-5661-44ea-92b4-6216ed4f88ec
relation.isProjectOfPublication.latestForDiscoverybe9e472b-5661-44ea-92b4-6216ed4f88ec

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