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A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers

2023Journal article Open access
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dc.contributor.authorCorreia, Bárbara
dc.contributor.authorOliveira, Daniela
dc.contributor.authorVulpe, Georgeta
dc.contributor.authorTavares, Ana P. M.
dc.contributor.authorSales, M. Goreti F.
dc.contributor.authorDuarte, Abel J.
dc.contributor.authorSharma, Sanjiv
dc.contributor.authorMoreira, Felismina T. C.
dc.date.accessioned2024-04-24T15:16:15Z
dc.date.available2024-04-24T15:16:15Z
dc.date.issued2023
dc.description.abstractWhilst single use point of care testing (PoCT) devices have transformed healthcare globally, there are major concerns over their environmental consequences. These concerns could be addressed by employing devices made of environmentally friendly materials. Herein, we report on the use of cork based PoCT devices. Cork is known to be fully biodegradable and can be easily recycled without producing toxic residues. We report on how a cork-based substrate coupled with a molecularly imprinted polymer (MIP) that serves as an “artificial antibody” can be used for point-of-care testing of the pro-inflammatory biomarker interleukin 6 (IL-6). The featured PoCT device has an electrochemical transducer that provides the desired clinical dynamic range for blood and can measure concentrations as low as 1 pg mL−1, indicating its usefulness in point of care measurements for monitoring pathological disorders, worldwide. In addition, it has a huge environmental impact as it can reduce the waste generated by other polymeric/ceramic carriers used for the same purpose.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCorreia, B., Oliveira, D., Vulpe, G., Tavares, A.P.M., Sales, M.G.F., Duarte, A.J., Sharma, S., & Moreira, F.T.C. (2023). A cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkers. Sensors & Diagnostics, 2(4), 956-963. https://doi.org/10.1039/d3sd00022bpt_PT
dc.identifier.doi10.1039/D3SD00022Bpt_PT
dc.identifier.issn2635-0998
dc.identifier.urihttp://hdl.handle.net/10400.22/25409
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThe Royal Society of Chemistrypt_PT
dc.relation.publisherversionhttps://pubs.rsc.org/en/content/articlelanding/2023/sd/d3sd00022bpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectPoCT testing devicespt_PT
dc.subjectEnvironmental consequences.pt_PT
dc.subjectTesting devicespt_PT
dc.subjectCorkpt_PT
dc.titleA cork based substrate coupled with artificial antibodies for point-of-care detection of pro-inflammatory cytokine biomarkerspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage963pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage956pt_PT
oaire.citation.titleSensors & Diagnosticspt_PT
oaire.citation.volume2pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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