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Authors
Abstract(s)
Synthetic pyrethroids are pesticides derived from naturally occurring pyrethrins,
taken from pyrethrum of dried Chrysanthemum flowers. Pyrethroid insecticides are
one of the most commonly used residential and agricultural insecticides. Many
pyrethroids can significantly harm the nervous system. Permethrin could be one of
the factors involved in the onset of neurodegenerative diseases. The present study
aims to evaluate in brain, the effect that can induce the exposure to permethrin,
during early life of female rats (from 6 to 21 days of life). Therefore, have been
examined the concentrations of permethrin and its main metabolite (3-PBA) in the
brain and urine in female rats sacrificed the day after and 14 days after treating. The
different concentrations of permethrin and 3-PBA (after 24h and after 14 days in the
end of treatment) were obtained using two different methods. The evaluation of
permethrin by liquid-liquid extraction and GC-ECD was performed. The levels of the
3-PBA (in urine and brains) were obtained by SPE procedure and GC-MS using the 2-
PBA as internal standard.
Description
Keywords
Pesticides Pyrethroids Permethrin Brain toxicity 3-PBA (3- phenoxybenzoic acid) 2-PBA (2-phenoxybenzoic acid) SPE GC-ECD GC-MS