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Isothiazolinone Biocides: Chemistry, Biological, and Toxicity Profiles

2020-02-23Journal article Open access
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dc.contributor.authorSilva, Vânia
dc.contributor.authorSilva, Catia
dc.contributor.authorSoares, Pedro
dc.contributor.authorGarrido, E. Manuela
dc.contributor.authorBorges, Fernanda
dc.contributor.authorGarrido, J.
dc.date.accessioned2021-04-30T13:52:36Z
dc.date.available2021-04-30T13:52:36Z
dc.date.issued2020-02-23
dc.description.abstractThe importance of isothiazole and of compounds containing the isothiazole nucleus has been growing over the last few years. Isothiazolinones are used in cosmetic and as chemical additives for occupational and industrial usage due to their bacteriostatic and fungiostatic activity. Despite their effectiveness as biocides, isothiazolinones are strong sensitizers, producing skin irritations and allergies and may pose ecotoxicological hazards. Therefore, their use is restricted by EU legislation. Considering the relevance and importance of isothiazolinone biocides, the present review describes the state-of-the-art knowledge regarding their synthesis, antibacterial components, toxicity (including structure-activity-toxicity relationships) outlines, and (photo)chemical stability. Due to the increasing prevalence and impact of isothiazolinones in consumer's health, analytical methods for the identification and determination of this type of biocides were also discussed.pt_PT
dc.description.sponsorshipThe authors would like to acknowledge ANI for the support of the Project FAMEST 24529 by Portugal 2020 Programme. This project was supported by FEDER funds through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI) and by national funds through Foundation for Science and Technology (FCT) (Projects UID/QUI/00081/2019 and POCI-01-0145-FEDER-030219).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, V., Silva, C., Soares, P., Garrido, E.M., Borges, F., Garrido, J., “Isothiazolinone biocides: Chemistry, biological, and toxicity profiles. (2020) Molecules, 25 (4), art. no. 991, DOI: https://doi.org/10.3390/molecules25040991pt_PT
dc.identifier.doi10.3390/molecules25040991pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/17876
dc.language.isoengpt_PT
dc.relationFAMEST 24529pt_PT
dc.relationChemistry Research Unit of University of Porto
dc.subjectBiocidespt_PT
dc.subjectIsothiazolespt_PT
dc.subjectIsothiazolinonespt_PT
dc.subjectChemistrypt_PT
dc.subjectBiological/toxicity relationshipspt_PT
dc.subjectStabilitypt_PT
dc.subjectAnalysispt_PT
dc.titleIsothiazolinone Biocides: Chemistry, Biological, and Toxicity Profilespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleChemistry Research Unit of University of Porto
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00081%2F2019/PT
oaire.citation.issue4pt_PT
oaire.citation.startPage991pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume25pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSoares
person.familyNameGarrido
person.familyNameGarrido
person.givenNameCatia
person.givenNameE. Manuela
person.givenNameJorge
person.identifier.ciencia-id1A12-6581-ECDD
person.identifier.ciencia-id0219-E083-0653
person.identifier.orcid0000-0001-7592-5954
person.identifier.orcid0000-0001-9050-6168
person.identifier.orcid0000-0001-8981-231X
person.identifier.scopus-author-id56035326800
person.identifier.scopus-author-id7004992709
person.identifier.scopus-author-id7202779733
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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