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The Optical Clearing Method: A New Tool for Clinical Practice and Biomedical Engineering

2019Book Restricted access
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dc.contributor.authorOliveira, Luís Manuel Couto
dc.contributor.authorTuchin, Valery Victorovich
dc.date.accessioned2020-01-17T10:46:38Z
dc.date.available2020-01-17T10:46:38Z
dc.date.issued2019
dc.description.abstractThis book describes the Optical Immersion Clearing method and its application to acquire information with importance for clinical practice and various fields of biomedical engineering. The method has proved to be a reliable means of increasing tissue transparency, allowing the investigator or surgeon to reach deeper tissue layers for improved imaging and laser surgery. This result is obtained by partial replacement of tissue water with an active optical clearing agent (OCA) that has a higher refractive index and is a better match for the refractive index of other tissue components. Natural tissue scattering is thereby reduced. An exponential increase in research using this method has occurred in recent years, and new applications have emerged, both in clinical practice and in some areas of biomedical engineering. Recent research has revealed that treating ex vivo tissues with solutions containing active OCAs in different concentrations produces experimental data to characterize drug delivery or to discriminate between normal and pathological tissues. The obtained drug diffusion properties are of interest for the pharmaceutical and organ preservation industry. Similar data can be estimated with particular interest for food preservation. The free water content evaluation is also of great interest since it facilitates the characterization of tissues to discriminate pathologies. An interesting new application that is presented in the book regards the creation of two optical windows in the ultraviolet spectral range through the application of the immersion method. These induced transparency windows open the possibility to diagnose and treat pathologies with ultraviolet light. This book presents photographs from the tissues we have studied and figures that represent the experimental setups used. Graphs and tables are also included to show the numerical results obtained in the sequential calculations performed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/978-3-030-33055-2pt_PT
dc.identifier.isbn978-3-030-33054-5
dc.identifier.urihttp://hdl.handle.net/10400.22/15297
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/book/10.1007/978-3-030-33055-2#tocpt_PT
dc.subjectOptical Immersion Clearing methodpt_PT
dc.subjectOptical Clearing Agentspt_PT
dc.subjectOptical Clearing mechanismspt_PT
dc.subjectMeasurements during Optical Clearingpt_PT
dc.subjectIncreasing tissue transparencypt_PT
dc.subjectDiffusion properties of chemicals in biological tissuespt_PT
dc.subjectFree water content in biological tissuespt_PT
dc.subjectPathology diagnosis with optical methodspt_PT
dc.subjectOptical properties of biological tissuespt_PT
dc.titleThe Optical Clearing Method: A New Tool for Clinical Practice and Biomedical Engineeringpt_PT
dc.typebook
dspace.entity.typePublication
oaire.citation.titlePart of the SpringerBriefs in Physics book series (SpringerBriefs in Physics)pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typebookpt_PT

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