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Molecularly Imprinted Solid Phase Extraction Aiding the Analysis of Disease Biomarkers

2020Journal article Open access
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dc.contributor.authorSilva, Matheus Siqueira
dc.contributor.authorTavares, Ana Patricia Moreira
dc.contributor.authorFaria, Henrique Dipe de
dc.contributor.authorSales, Maria Goreti Ferreira
dc.contributor.authorFigueiredo, Eduardo Costa
dc.date.accessioned2021-09-27T14:09:49Z
dc.date.available2021-11-01T01:30:26Z
dc.date.issued2020
dc.description.abstractLow concentrations of biomarkers as well as the complexity of biological samples make the clinical diagnoses of several diseases a challenging task. Sample preparation protocols remain a fundamental piece in the puzzle of analytical processes, and smart sorbents including molecularly imprinted polymers (MIPs) have been successfully used in this case. In this review, we depict the state of art for the rational design of MIPs to be used in solid phase extraction of disease biomarkers from biological samples. The topics are divided into (1) strategies for MIP syntheses, (2) setups for sample preparation protocols with MIPs, (3) the applications of these combined principles in the analyses of different classes of disease biomarkers, and (4) remaining challenges and future trends for the application of Molecular Imprinting Technology in sample preparation for clinical diagnosis.pt_PT
dc.description.sponsorshipThe authors are thankful to the Fundação à Pesquisa do Estado de Minas Gerais (FAPEMIG, Belo Horizonte, Brazil); the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brasilia, Brazil) and the Coordination for the Improvement of Higher Education Personnel (CAPES, Brasilia, Brazil) for financial support (process 88881.133746/2016-01) and the scholarship funding for Matheus Siqueira Silva/PDSE/ Processo no. {88881.133746/2016-01}.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1080/10408347.2020.1843131pt_PT
dc.identifier.issn1040-8347
dc.identifier.urihttp://hdl.handle.net/10400.22/18571
dc.language.isoengpt_PT
dc.publisherTaylor and Francispt_PT
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1080/10408347.2020.1843131pt_PT
dc.subjectBiological samplespt_PT
dc.subjectDisease biomarkerspt_PT
dc.subjectMolecularly imprinted polymerspt_PT
dc.subjectSample preparationpt_PT
dc.subjectSolid phase extractionpt_PT
dc.titleMolecularly Imprinted Solid Phase Extraction Aiding the Analysis of Disease Biomarkerspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage16pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleCritical Reviews in Analytical Chemistrypt_PT
person.familyNameTavares Moreira
person.familyNameFerreira Sales
person.givenNameAna Patricia
person.givenNameMaria Goreti
person.identifier826970
person.identifier.ciencia-id3F13-6815-3A93
person.identifier.ciencia-idE31F-1630-42BB
person.identifier.orcid0000-0003-2868-3037
person.identifier.orcid0000-0001-9936-7336
person.identifier.ridK-9199-2013
person.identifier.scopus-author-id7005174717
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7168c35f-4b1b-4c79-b582-7982889bf3f7
relation.isAuthorOfPublicationb6d3a2d0-608a-4a92-834b-8d7b29069fef
relation.isAuthorOfPublication.latestForDiscovery7168c35f-4b1b-4c79-b582-7982889bf3f7

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