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Advisor(s)
Abstract(s)
The study of chemical diffusion in biological tissues is a research field of high
importance and with application in many clinical, research and industrial areas. The
evaluation of diffusion and viscosity properties of chemicals in tissues is necessary to
characterize treatments or inclusion of preservatives in tissues or organs for low
temperature conservation. Recently, we have demonstrated experimentally that the
diffusion properties and dynamic viscosity of sugars and alcohols can be evaluated from
optical measurements. Our studies were performed in skeletal muscle, but our results
have revealed that the same methodology can be used with other tissues and different
chemicals. Considering the significant number of studies that can be made with this
method, it becomes necessary to turn data processing and calculation easier. With this
objective, we have developed a software application that integrates all processing and
calculations, turning the researcher work easier and faster. Using the same experimental
data that previously was used to estimate the diffusion and viscosity of glucose in
skeletal muscle, we have repeated the calculations with the new application. Comparing
between the results obtained with the new application and with previous independent
routines we have demonstrated great similarity and consequently validated the
application. This new tool is now available to be used in similar research to obtain the
diffusion properties of other chemicals in different tissues or organs.
Description
Keywords
Collimated optical transmittance Software application Viscosity Thickness variation Refractive index matching Optical clearing Glucose Chemical diffusion in tissues
Citation
Publisher
Samara State Aerospace University