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- Assessing the management of excessive daytime sleepiness by napping benefitsPublication . Murillo-Rodríguez, Eric; Yamamoto, Tetsuya; Monteiro, Diogo; Budde, Henning; Rocha, Nuno; Cid, Luis; Teixeira, Diogo S.; Telles-Correia, Diogo; Veras, André Barciela; Machado, Sérgio; Imperatori, Claudio; Torterolo, PabloPurpose Demanding lifestyle characterized by extended working hours, shift work schedules as well as excessive use of mobile gadgets leads to the disruption of the circadian and homeostatic factors affecting the sleep quality of individuals. As consequence, subjects complain of suffering several sleep disorders some of them characterized by inducing excessive daytime sleepiness (EDS). Currently, the therapeutic approaches for managing EDS include medication, promotion of sleep hygiene, cognitive and behavioral therapy or using of continuous positive airway pressure machine. In this review, we propose the posology of the personalized sleep medicine by the prescription of naps for treating EDS. Methods This review included the online search in PubMed and manual review of articles (basic and clinical trials) of a range of personalized medicine potentially associated to factors of dosage in areas such as nutrition, sports and sleep. Articles in English were identified and subsequently analyzed for consideration for this review. Results Current evidence has demonstrated that naps exert positive outcomes for individuals complaining with EDS. The dosage of naps might follow similar procedures as reported for personalized interventions in diets or exercise programs (by taking the right dose, at the proper time, with a recommended frequency) which have demonstrated successfully results. Conclusions The management of EDS may include the personalized sleep medicine considering the prescription of dosage of naps.
- Exercise induced neuroplasticity to enhance therapeutic outcomes of cognitive remediation in schizophrenia: Analyzing the role of brain-derived neurotrophic factorPublication . Campos, C.; Rocha, Nuno; Lattari, Eduardo; Nardi, António E.; Machado, SérgioCognitive impairment is a major manifestation of schizophrenia and a crucial treatment target as these deficits are closely related to patients' functional outcomes. Cognitive remediation is the gold-standard practice to address cognitive deficits in schizophrenia. There is clear evidence stating that cognitive remediation improves cognitive function and promotes structural neuroplastic changes in patients with schizophrenia, with brain-derived neurotrophic factor (BDNF) expression emerging as a potential biomarker for its efficacy. This is particularly important as there is clear evidence relating atypical BDNF expression to cognitive impairment in patients with schizophrenia. Despite the valuable role of cognitive remediation in the management of schizophrenia, there is still a need to develop methods that allow maximizing its efficacy.
- Exercise-induced neuroprotective effects on neurodegenerative diseases: the key role of trophic factorsPublication . Campos, Carlos; Rocha, Nuno; Lattari, Eduardo; Paes, Flávia; Nardi, António E.; Machado, SérgioAge-related neurodegenerative disorders, like Alzheimer’s or Parkinson’s disease, are becoming a major issue to public health care. Currently, there is no effective pharmacological treatment to address cognitive impairment in these patients. Here, we aim to explore the role of exercise-induced trophic factor enhancement in the prevention or delay of cognitive decline in patients with neurodegenerative diseases.