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- FOXO3-REST Axis: a therapeutic target for medulloblastoma?Publication . Monteiro, Ricardo; Baiula, Mónica; Santos, Marlene; Spampinato, SantiMedulloblastoma has poor outcome due also to adverse events caused by the treatment [1]. An improved anti-tumor strategy is needed to enhance patient survival rate. REST is a transcription factor overexpressed in medulloblastoma cells and it’s associated with the formation of this brain tumor and the low survival rate, suggesting an oncogenic role [2][3].