Browsing by Author "Teixeira, Joana"
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- Exposure to PAHs during Firefighting Activities: A Review on Skin Levels, In Vitro/In Vivo Bioavailability, and Health RisksPublication . Sousa, Gabriel; Teixeira, Joana; Delerue-Matos, Cristina; Sarmento, Bruno; Morais, Simone; Wang, Xianyu; Rodrigues, Francisca; Oliveira, MartaOccupational exposure as a firefighter is a complex activity that continuously exposes subjects to several health hazards including fire emissions during firefighting. Firefighters are exposed to polycyclic aromatic hydrocarbons (PAHs), known as toxic, mutagenic, and carcinogenic compounds, by inhalation, dermal contact, and ingestion. In this work, a literature overview of firefighters’ dermal exposure to PAHs after firefighting and data retrieved from skin in vitro/in vivo studies related to their dermal absorption, bioavailability, and associated toxicological and carcinogenic effects are reviewed. The evidence demonstrates the contamination of firefighters’ skin with PAHs, mainly on the neck (2.23–62.50 ng/cm2), wrists (0.37–8.30 ng/cm2), face (2.50–4.82 ng/cm2), and hands (1.59–4.69 ng/cm2). Concentrations of possible/probable carcinogens (0.82–33.69 ng/cm2), including benzopyrene isomers, were found on firefighters’ skin. PAHs penetrate the skin tissues, even at low concentrations, by absorption and/or diffusion, and are locally metabolized and distributed by the blood route to other tissues/organs. Lighter PAHs presented increased dermal permeabilities and absorption rates than heavier compounds. Topical PAHs activate the aryl hydrocarbon receptor and promote the enzymatic generation of reactive intermediates that may cause protein and/or DNA adducts. Future research should include in vitro/in vivo assays to perform a more realistic health risk assessment and to explore the contribution of dermal exposure to PAHs total internal dose
- Microcytic anemia factor no estudo das anemias microcíticasPublication . Teixeira, Joana; Barros, ClaraA anemia ferropénica e a β-Talassemia menor são as anemias microcíticas mais frequentes na prática laboratorial, sendo o seu diagnóstico de extrema importância clínica. O objectivo deste estudo consistiu na análise do poder discriminatório do MAF na caracterização destas anamias. Foi desenvolvido um estudo caso-controlo, tendo sido analisados os hemogramas de um grupo de 47 indivíduos com anemia ferropénica e 37 com β-talassemia, e de um grupo controlo constituído por 58 indivíduos saudáveis. Na diferenciação dos grupos patológicos, apenas a Hemoglobina, o VGM e o RDW apresentaram diferenças significativas. O MAF não demonstrou poder discriminatório relativamente às anemias microcíticas.
- Potenciais usos e efeitos terapêuticos da 3,4-metilenodioximetanfetamina (MDMA): revisão sistemáticaPublication . Teixeira, Jéssica; Teixeira, Joana; Correia, Patrícia; Pinho, Cláudia; Correia, Patrícia Carla dos Santos Correia; Pinho, CláudiaA MDMA (3,4-metilenodioximetanfetamina) é uma droga sintética consumida recreativamente. No entanto, o seu potencial terapêutico tem sido alvo de estudos. Esta revisão pretende sintetizar os potenciais usos e efeitos terapêuticos da MDMA pura em humanos, em contexto controlado.
- Supplier's selection model based on an empirical studyPublication . Ávila, Paulo; Mota, Alzira; Pires, António; Bastos, João; Putnik, Goran; Teixeira, JoanaThe problem of selecting suppliers/partners is a crucial and important part in the process of decision making for companies that intend to perform competitively in their area of activity. The selection of supplier/partner is a time and resource-consuming task that involves data collection and a careful analysis of the factors that can positively or negatively influence the choice. Nevertheless it is a critical process that affects significantly the operational performance of each company. In this work, there were identified five broad selection criteria: Quality, Financial, Synergies, Cost, and Production System. Within these criteria, it was also included five sub-criteria. After the identification criteria, a survey was elaborated and companies were contacted in order to understand which factors have more weight in their decisions to choose the partners. Interpreted the results and processed the data, it was adopted a model of linear weighting to reflect the importance of each factor. The model has a hierarchical structure and can be applied with the Analytic Hierarchy Process (AHP) method or Value Analysis. The goal of the paper it's to supply a selection reference model that can represent an orientation/pattern for a decision making on the suppliers/partners selection process