Browsing by Author "Alves, A."
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- Feasibility of a mobile app to improve inhaler adherence in real‐world patients with asthma: A multicentre observational study in Portugal and SpainPublication . Jácome, Cristina; Rute, Almeida; Amaral, Rita; Pereira, Ana Margarida; Vidal, Carmen; Freire, Sara Lopéz; Mendez Brea, Paula; Antolín- Amerigo, Dario; De La Hoz Caballer, Belen; Barra Castro, Alicia; González de Olano, David; Todo-Bom, Ana; Azevedo, João; Pinto, Paula Leiria; Neuparth, Nuno; Todo-Bom, Filipa; Costa, A.; Loureiro, Cláudia Chaves; Maia Santos, L.; Arrobas, Ana Maria; Valério, M.; Cardoso, João; Emiliano, Madalena; Gerardo, Rita; Cidrais Rodrigues, J. C.; Oliveira, G.; Carvalho, J.; Mendes, Ana; Lozoya, Carlos; Santos, Natacha; Menezes, F.; Gomes, Ricardo; Câmara, R.; Rodrigues Alves, Rodrigo; Moreira, Ana Sofia; Bordalo, Diana; Alves, C.; Coelho, D.; Ferreira, J. A.; Lopes, Cristina; Vasconcelos, M. J.; Teixeira, M. F.; Taborda-Barata, L.; Cálix, M. J.; Alves, A.; Almeida Fonseca, J.InspirerMundi app aims to transform adherence into a positive experience through gamification and social support, while allowing objective monitoring of inhaler adherence. This study assessed the feasibility of the app in adolescents and adults with persistent asthma.
- Human dermal exposure to galaxolide from personal care productsPublication . Correia, Patrícia; Cruz, Agostinho; Santos, L.; Alves, A.Musks are synthetic fragrances applied on personal care and household products as fixatives, by retarding the release of other fragrances with higher volatility. Galaxolide is the most used polycyclic musk since the 90th decade, and it has been detected in several environmental and biological matrices, particularly in human tissues and fluids. For exposure assessment purposes, large-monitoring data need to be obtained and rapid but reliable analytical techniques are requested. The main objective of this study is to develop and validate a new and fast analytical methodology to quantify galaxolide in personal care products and to apply this method to real matrices like skin care products (creams and lotions), shower products (soap bar), hair care products (shampoo and hair conditioner) and oral care products (toothpaste), to evaluate the human dermal exposure risk. A dispersive solid-phase extraction is proposed, using QuEChERS methodology, followed by HPLC with fluorescence detection. Some extraction parameters were studied, like the ratio of sample/solvent amounts, the homogenization time, the salt addition effect and the used sorbents. The validation parameters of the developed method were the following: a linearity range of 0.005-1.002 mg kg⁻¹ sample, a limit of detection of 0.001 mg kg⁻¹ sample, repeatability between 0.7% and 11.3% (variation coefficient of six standard injections), an intermediate precision of 2.5% (variation coefficient of six independent analysis of the same sample), mean recoveries ranging from 65% (soap bar) to 95% (body cream) and 3% of global uncertainty in most of the working range. The time of analysis, including the extraction steps, is 60 min, allowing a throughput of 4 samples h⁻¹ . Galaxolide was detected in all of the seven analysed products in concentrations ranging from 0.04 ± 0.01 mg kg⁻¹ sample (toothpaste) to 280.78 ± 8.19 mg kg⁻¹ sample (perfumed body cream), which may correspond to a significant estimated daily human dermal exposure of 904 μg day⁻¹.
- Sorption behaviour of bifenthrin on corkPublication . Domingues, Valentina F.; Alves, A.; Cabral, Miguel; Delerue-Matos, CristinaBiphentrin, a known pyrethroid, was studied, aiming its removal from aqueous solutions by granulated cork sorption. Batch experiments, either for equilibrium or for kinetics, with two granulated cork sizes were performed and results were compared with those obtained with of activated carbon sorption. Langmuir and Freundlich adsorption isotherms were obtained both showing high linear correlations. Bifenthrin desorption was evaluated for cork and results varied with the granule size of sorbent. The results obtained in this work indicate that cork wastes may be used as a cheap natural sorbent for bifenthrin or similar compounds removal from wastewaters.