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Methylphenidate and P300 in attention deficit hyperactivity disorder: A systematic review and meta-analysis

2025-03-15Research article Embargoed access
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dc.contributor.authorBarroso, Beatriz C. R.
dc.contributor.authorMendonça, Fabiana
dc.contributor.authorMazer, Prune
dc.contributor.authorPrata, Catarina
dc.contributor.authorPinto, Joana O.
dc.contributor.authorMazer, Prune
dc.contributor.authorPinto, Joana O
dc.date.accessioned2025-05-12T15:08:39Z
dc.date.available2025-05-12T15:08:39Z
dc.date.issued2025-03-15
dc.description.abstractMethylphenidate (MPH) is a stimulant medicine often used to treat attention deficit hyperactivity disorder (ADHD), as it may positively affect behaviour and brain activity. This work aims to systematise the current literature about the effects of MPH on the amplitude of P300 in individuals with ADHD. A systematic review and meta-analysis of empirical studies measuring P300 amplitude and comparing MPH administration to either a pre-MPH condition or healthy controls was conducted, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Our results revealed no overall (n = 13) significant differences between individuals diagnosed with ADHD and medicated with MPH and controls. Although, a moderation analysis by region found differences between both groups on frontal sites. When comparing the pre- and post-effects of MPH on the same individuals (n = 17), it appears that P300 amplitude tends to increase post-administration in central and posterior regions. In this second meta-analysis, a moderation by task revealed a larger effect size for go/no-go. In general, MPH was found to increase P300 amplitude in ADHD, somewhat normalising this aspect of their brain activity. The main limitations of the included studies are the insufficiently explained dosages and the skewness for male participants. Future research directions are discussed.por
dc.identifier.citationC. R. Barroso, B., Mendonça, F., Mazer, P., Prata, C., & Pinto, J. O. (2025). Methylphenidate and P300 in attention deficit hyperactivity disorder: A systematic review and meta-analysis. International Journal of Psychophysiology, 211, 112553. https://doi.org/10.1016/j.ijpsycho.2025.112553
dc.identifier.doi10.1016/j.ijpsycho.2025.112553
dc.identifier.eissn1872-7697
dc.identifier.issn0167-8760
dc.identifier.urihttp://hdl.handle.net/10400.22/30068
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation2021.07199.BD
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0167876025000492?via%3Dihub
dc.rights.uriN/A
dc.subjectADHD
dc.subjectERP/EEG
dc.subjectP300
dc.subjectMethylphenidate
dc.subjectMeta-analysis
dc.titleMethylphenidate and P300 in attention deficit hyperactivity disorder: A systematic review and meta-analysispor
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.titleInternational Journal of Psychophysiology
oaire.citation.volume211
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMazer
person.familyNamePinto
person.givenNamePrune
person.givenNameJoana O
person.identifier.ciencia-idB91F-426D-7D76
person.identifier.ciencia-id431A-BDD1-63C2
person.identifier.orcid0000-0003-4747-5356
person.identifier.orcid0000-0002-0643-8439
relation.isAuthorOfPublicationc85918ab-cdc8-4da8-8a80-95b59f4bd84e
relation.isAuthorOfPublication9f253dfa-a8af-4aed-8258-8700464adcf1
relation.isAuthorOfPublication.latestForDiscoveryc85918ab-cdc8-4da8-8a80-95b59f4bd84e

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