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Resumo(s)
O Factor Neurotrófico Derivado do Cérebro (BDNF) está associado a processos de crescimento, diferenciação e sobrevivência das células neuronais. A expressão diferencial do BDNF, particularmente no hipocampo, está relacionada com a manifestação clínica de algumas doenças do foro psiquiátrico e cognitivo como a doença de Huntington, Alzheimer, depressão e esquizofrenia.
Este trabalho pretende dar conhecimento das técnicas utilizadas para avaliar a expressão do gene BDNF. As técnicas de ELISA, IHC e Western blot, por permitirem a avaliação precisa da expressão de BDNF, são úteis para uma melhor compreensão, diagnóstico e tratamento de algumas doenças neurodegenerativas.
The Brain-Derived Neurotrophic Factor (BDNF) is associated with processes of growth, differentiation and survival of neuronal cells. The differential expression of BDNF, particularly in the hippocampus, is related to the clinical manifestation of some psychiatric and cognitive diseases like Huntington's disease, Alzheimer's, depression and schizophrenia. This work aims to give knowledge of techniques used to evaluate the expression of the BDNF gene. The techniques of ELISA, IHC and Western blot, by allowing precise evaluation of the expression of BDNF, are useful for improved understanding, diagnosis and treatment of some neurodegenerative diseases.
The Brain-Derived Neurotrophic Factor (BDNF) is associated with processes of growth, differentiation and survival of neuronal cells. The differential expression of BDNF, particularly in the hippocampus, is related to the clinical manifestation of some psychiatric and cognitive diseases like Huntington's disease, Alzheimer's, depression and schizophrenia. This work aims to give knowledge of techniques used to evaluate the expression of the BDNF gene. The techniques of ELISA, IHC and Western blot, by allowing precise evaluation of the expression of BDNF, are useful for improved understanding, diagnosis and treatment of some neurodegenerative diseases.
Descrição
Palavras-chave
Factor neurotrófico derivado do cérebro (BDNF) Doenças neurodegenerativas ELISA Imunohistoquímica (IHC) Western blot Brain-derived neurotrophic factor (BDNF) Neurodegenerative diseases Immunohistochemistry (IHC)
Contexto Educativo
Citação
Oliveira, T., Pontes, M., & Neto, F. (2010). Avaliação da expressão do gene BDNF em doenças neurodegenerativas. 1 st ICH Gaia-Porto, 151–156. https://recipp.ipp.pt/handle/10400.22/1302
Editora
Instituto Politécnico do Porto. Escola Superior de Tecnologia da Saúde do Porto - Politema