Repository logo
 
Publication

Exploring the bioactive potential of Pisolithus (Basidiomycota): comprehensive insights into antimicrobial, anticancer, and antioxidant properties for innovative applications

2024-02-23Journal article Open access
Simple item page
dc.contributor.authorS. Oliveira, Rui
dc.contributor.authorPreto, Marco
dc.contributor.authorSantos, Germana
dc.contributor.authorSilva, Ana Margarida
dc.contributor.authorVasconcelos, Vitor
dc.contributor.authorMartins, Rosário
dc.date.accessioned2024-02-28T13:03:20Z
dc.date.available2024-02-28T13:03:20Z
dc.date.issued2024-02-23
dc.description.abstractAddressing pressing health concerns, modern medical research seeks to identify new antimicrobials to combat drug resistance, novel molecules for cancer treatment, and antioxidants for inflammation-related diseases. Pisolithus (Basidiomycota) is a ubiquitous and widely distributed fungal genus in forest ecosystems, known for establishing ectomycorrhizal associations with a range of host plants, enhancing their growth, and conferring protection against biotic and abiotic stresses. Beyond ecological applications, Pisolithus yields bioactive compounds with medicinal potential. This comprehensive review explores the transversal biological activity of Pisolithus fungi, aiming to provide a thorough overview of their antimicrobial, anticancer, and antioxidant potential. The focus is on elucidating bioactive compounds within Pisolithus to trigger further research for innovative applications. Compounds from Pisolithus displayed antimicrobial activity against a broad spectrum of microorganisms, including antibiotic-resistant bacteria. The efficacy of Pisolithus-derived compounds matched established medications, emphasizing their therapeutic potential. In anticancer research, the triterpene pisosterol stood out with documented cytotoxicity against various cancer cell lines, showcasing promise for novel anticancer therapies. Pisolithus was also recognized as a potential source of antioxidants, with basidiocarps exhibiting high antioxidant activity. In vivo validation and comprehensive studies on a broader range of compounds, together with mechanistic insights into the mode of action of Pisolithus-derived compounds, are compelling areas for future research.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOliveira, R. S., Preto, M., Santos, G., Silva, A. M., Vasconcelos, V., & Martins, R. (2024). Exploring the Bioactive Potential of Pisolithus (Basidiomycota): Comprehensive Insights into Antimicrobial, Anticancer, and Antioxidant Properties for Innovative Applications. Microorganisms, 12(3), Artigo 3. https://doi.org/10.3390/microorganisms12030450pt_PT
dc.identifier.doi10.3390/microorganisms12030450pt_PT
dc.identifier.issn2076-2607
dc.identifier.urihttp://hdl.handle.net/10400.22/25090
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationhis work was supported by FCT—Fundação para a Ciência e Tecnologia, I.P. by project reference UIDB/04004/2020 and DOI identifier 10.54499/UIDB/04004/2020 (https://doi.org/10.54499/UIDB/04004/2020, accessed on 17 February 2024), to the Centre for Functional Ecology—Science for People & the Planet, and by the European Regional Development Fund (ERDF) through the Regional Operational Program North 2020, within the scope of Project GreenHealth—Digital strategies in biological assets to improve well-being and promote green health, Norte-01-0145-FEDER-000042. The authors are also grateful to FCT financial support to CIIMAR (UIDB/04423/2020 and UIDP/04423/2020).pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-2607/12/3/450pt_PT
dc.subjectBiological activitypt_PT
dc.subjectFungipt_PT
dc.subjectNatural compoundspt_PT
dc.subjectPisolithus arhizuspt_PT
dc.subjecttinctoriuspt_PT
dc.subjectPisolithuspt_PT
dc.titleExploring the bioactive potential of Pisolithus (Basidiomycota): comprehensive insights into antimicrobial, anticancer, and antioxidant properties for innovative applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage16pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMicroorganismspt_PT
oaire.citation.volume12(3)pt_PT
person.familyNameMartins
person.givenNameRosario
person.identifier.ciencia-idA919-DB40-EF10
person.identifier.orcid0000-0002-9882-4651
person.identifier.scopus-author-id21834368700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication82a7c349-c88e-450f-adc7-3331d69149cf
relation.isAuthorOfPublication.latestForDiscovery82a7c349-c88e-450f-adc7-3331d69149cf

Files

License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESS - CM - Artigos