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Assessment of exposure to polycyclic aromatic hydrocarbons inpreschool children: Levels and impact of preschool indoor air onexcretion of main urinary monohydroxyl metabolites

2017Journal article Restricted access
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dc.contributor.authorOliveira, Marta
dc.contributor.authorSlezakova, Klara
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorPereira, Maria do Carmo
dc.contributor.authorMorais, Simone
dc.date.accessioned2017-01-26T10:45:59Z
dc.date.embargo2117
dc.date.issued2017
dc.description.abstractThe present work aimed to assess exposure of preschool children to polycyclic aromatic hydrocar-bons (PAHs) by environmental monitoring (eighteen compounds in air) and biomonitoring (six urinary biomarkers of exposure (OH-PAHs)). The impact of preschool indoor air on excretion of urinary mono-hydroxyl metabolites was also evaluated. Gaseous and particulate-bound PAHs were simultaneously collected indoors and outdoors in two Portuguese preschools. PAHs and OH-PAHs were quantified by high-performance liquid chromatography with fluorescence and photodiode array detection. Total air (gaseous + total suspended particles) levels of PAHs (􀀁PAHs) were higher indoors than outdoors. Gaseous phase (composed by ≥98% of 2–3 rings compounds) and particulate-bound PAHs (90–99% of 5–6 rings) accounted for 93–95% and 5–7% of 􀀁PAHs in indoor air, respectively. Total (including probable/possible) carcinogenic PAHs represented 26–45% of 􀀁PAHs; naphthalene and dibenz[a,h]anthracene were the strongest contributors. A similar distribution profile was observed between airborne PAHs and uri-nary OH-PAHs. Urinary 1-hydroxynaphthalene + 1-hydroxyacenaphthene represented more than 78%of 􀀁OH-PAHs, being followed by 2-hydroxyfluorene, 1-hydroxypyrene, and 1-hydroxyphenanthrene. 3-hydroxybenzo[a]pyrene (PAH biomarker of carcinogenicity) was not detected. Results suggest that children had preschool indoor air as their major exposure source of naphthalene and acenaphthene, while no conclusion was reached regarding fluorene, phenanthrene and pyrene.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttp://dx.doi.org/10.1016/j.jhazmat.2016.10.004pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/9425
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relation.ispartofseriesJournal of Hazardous Materials;Vol. 322, Part B
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0304389416309013pt_PT
dc.subjectChildren exposurept_PT
dc.subjectDiagnostic ratiospt_PT
dc.subjectIndoor/outdoor ratiospt_PT
dc.subjectMonitoring and biomonitoringpt_PT
dc.subjectPolycyclic aromatic hydrocarbons (PAHs)pt_PT
dc.titleAssessment of exposure to polycyclic aromatic hydrocarbons inpreschool children: Levels and impact of preschool indoor air onexcretion of main urinary monohydroxyl metabolitespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issuePart Bpt_PT
oaire.citation.titleJournal of Hazardous Materialspt_PT
oaire.citation.volume322pt_PT
person.familyNameDelerue-Matos
person.familyNameMorais
person.givenNameCristina
person.givenNameSimone
person.identifier1598822
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.ciencia-idB111-BBFB-F200
person.identifier.orcid0000-0002-3924-776X
person.identifier.orcid0000-0001-6433-5801
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id6603741848
person.identifier.scopus-author-id7007053747
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication7a9c7d63-a6c7-4159-b12d-b049b8c5c8f9
relation.isAuthorOfPublication.latestForDiscovery7a9c7d63-a6c7-4159-b12d-b049b8c5c8f9

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