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Dose-response to different radiochemotherapy regimens in locally advanced pancreatic cancer

2019-09Book part Restricted access
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dc.contributor.authorCosta Ferreira, Brígida
dc.contributor.authorDias, Joana
dc.contributor.authorGomes, Adriana
dc.contributor.authorMavroidis, Panayiotis
dc.contributor.authorRocha, Humberto
dc.date.accessioned2021-11-16T10:31:24Z
dc.date.available2021-11-16T10:31:24Z
dc.date.issued2019-09
dc.description.abstractConformal radiation therapy (RT) delivered concomitantly with chemotherapy including 5-fluorouracil (5-FU) or Gemcitabine (GEM) is a common treatment for patients with unresectable locally advanced pancreatic tumors. In this study, the Poisson model describing tumor response to these two treatment options was derived. Clinical data was retrieved from reports pub lished from 1990 to 2015. Dosimetric and clinical data from 1196 patients treated with RT with concurrent 5-FU or GEM were gathered. RT doses ranging from 3.6–64.8 Gy, delivered in fractions of 1.2–8 Gy, were converted to a 2 Gy fractionation scheme using the Biological Effective Dose concept. The param eters of the Poisson-Linear-Quadratic-Time model were derived using genetic algorithm optimization to minimize the least-square fitting error and a local search was then made using the maximum likelihood method. The goodness of the fit was assessed using the Pearson v2 -test. For RT+5-FU, D50 was 59.8 Gy, c was 1.3, a/b was 3.2, Tpot was 18.6 days and Tk was 25.0 days. For RT+GEM, D50 was 54.5 Gy, c was 1.4, a/b was 4.6, Tpot was 34.2 days and Tk was 37.2 days. As expected, RT+GEM showed higher efficacy than RT+5-FU. A RT dose-response effect was obtained showing that treatment strategies allowing a dose-escalation in pancreas tumors should be investigatedpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira, B. C., Dias, J., Gomes, A., Mavroidis, P., & Rocha, H. (2019). Dose-Response to Different Radiochemotherapy Regimens in Locally Advanced Pancreatic Cancer. In J. Henriques, N. Neves, & P. d. Carvalho (Eds.), XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019 (Vol. 76). Springer. https://doi.org/10.1007/978-3-030-31635-8_156pt_PT
dc.identifier.doi10.1007/978-3-030-31635-8_156pt_PT
dc.identifier.isbn978-3-030-31634-1
dc.identifier.urihttp://hdl.handle.net/10400.22/18873
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/chapter/10.1007%2F978-3-030-31635-8_156pt_PT
dc.subjectPancreas tumorspt_PT
dc.subjectDose-response modelspt_PT
dc.subjectRadiation therapypt_PT
dc.subjectChemotherapypt_PT
dc.titleDose-response to different radiochemotherapy regimens in locally advanced pancreatic cancerpt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.conferencePlaceCoimbra - Portugalpt_PT
oaire.citation.endPage1282pt_PT
oaire.citation.startPage1276pt_PT
oaire.citation.titleXV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019pt_PT
oaire.citation.volume76pt_PT
person.familyNameCosta Ferreira
person.givenNameBrigida
person.identifier1167997
person.identifier.ciencia-idA61B-E07B-84B3
person.identifier.orcid0000-0001-7988-7545
person.identifier.scopus-author-id14050253300
rcaap.rightsclosedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublicationeac8b2c3-0ef3-48f5-a3c7-8ca796a098ae
relation.isAuthorOfPublication.latestForDiscoveryeac8b2c3-0ef3-48f5-a3c7-8ca796a098ae

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