Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/2896
Título: Fast screening procedure for antibiotics in wastewaters by direct HPLC-DAD analysis
Autor: Teixeira, Salomé
Delerue-Matos, Cristina
Alves, Arminda
Santos, Lúcia
Palavras-chave: Antibiotics
Data: 2008
Editora: WILEY-VCH Verlag GmbH & Co.
Resumo: Growing concern about the contamination of wastewaters by antibiotics demands fast but sensitive analytical methodologies, for the screening of a large number of samples. The purpose of this work was to develop a simple methodology, using direct injection of the samples, by HPLC with diode array detection (DAD), for a multiresidue analysis of five antibiotics of different classes. Wastewater from an urban water treatment plant was selected as a model to study possible coelution of interfering compounds. The linearity interval ranged from 40 to 400 µg/L for amoxicillin (Amox), metronidazole (Metro), cefazolin (Cefa), and chloramphenicol (Chloram) and from 20 to 200 µg/L for sulfamethoxazole (Sulfa), with LODs lower than 14 µg/L. Repeatability, expressed by the CV of six repeated injections, ranged from 1 to 8%, while the intermediate precision varied between 2 and 11%. The recovery ranged from 90 to 109%. This method enables the fast screening of a large number of samples, with an expanded uncertainty in the 1–22% range. The advantage of the proposed method is to significantly reduce the number of samples to be analyzed by more complex methods.
Peer review: yes
URI: http://recipp.ipp.pt/handle/10400.22/2896
Versão do Editor: http://www.interscience.wiley.com/
Aparece nas colecções:ISEP – GRAQ – Artigos

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