Ferreira, SaraLaranjo, MafaldaBrito, AnaAbrantes, Ana MargaridaMetello, Luís F.Zeevart, JanLouw, WernerDormehl, IreneBotelho, Maria Filomena2015-07-092015-07-092012http://hdl.handle.net/10400.22/6456188Re is a promising radionuclide for metabolic therapy because of the emission of high energy beta-particles. The development of water-soluble bone-seeking polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate- groups) that might be labeled with 188Re are recent approaches, with a strong potential for bone cancer treatment. The aim of this study was to evaluate the efficacy of 188Re- PEI-MP, as therapeutic agent for bone tumours, through in vitro and in vivo models.engother