Nogueira, LuísaAdubeiro, NunoNunes, Rita G.Nogueira, Luisa2026-05-292026-05-292025-12-05Nogueira, L., Adubeiro, N., & Nunes, R. G. (2026). Changing slopes: Can we be moving toward improved early treatment response prediction in breast cancer? European Radiology, 36(5), 4273–4275. https://doi.org/10.1007/s00330-025-12204-w0938-7994http://hdl.handle.net/10400.22/32469Breast cancer is the most common malignant cancer among women worldwide. For locally advanced disease and selected early-stage cases of human epidermal growth factor receptor 2 (HER-2)-positive and triple-negative breast cancers (TNBC), neoadjuvant chemotherapy (NAC) is the standard of care. NAC reduces tumor burden, facilitates axillary surgery de-escalation, increases the feasibility of breast-conserving surgery and aims to achieve a pathological complete response (pCR). Attaining pCR after NAC is associated with improved disease-free and overall survival rates, providing valuable prognostic information.engBreast cancerMalignant cancerHuman epidermaleditorial10.1007/s00330-025-12204-w1432-1084