Gaspar, Tiago BordeiraJesus, Tito TelesAzevedo, Maria TeresaMacedo, SofiaSoares, Mariana AlvesMartins, Rui SousaLeite, RúbenRodrigues, LiaRodrigues, Daniela FerreiraCardoso, LuísBorges, InêsCanberk, SuleGärtner, FátimaMiranda-Alves, LeandroLopes, José ManuelSoares, PaulaVinagre, João2024-05-202024-05-202023-06-01Gaspar, T. B., Jesus, T. T., Azevedo, M. T., Macedo, S., Soares, M. A., Martins, R. S., Leite, R., Rodrigues, L., Rodrigues, D. F., Cardoso, L., Borges, I., Canberk, S., Gärtner, F., Miranda-Alves, L., Lopes, J. M., Soares, P., & Vinagre, J. (2023). Generation of an obese diabetic mouse model upon conditional Atrx Disruption. Cancers, 15(11), Artigo 11. https://doi.org/10.3390/cancers15113018http://hdl.handle.net/10400.22/25532ATRX mutations occur in up to 17% of human pancreatic neuroendocrine tumours (PanNETs), and recent evidence points towards its inability to drive PanNET formation in mouse pancreas while predisposing individuals to inflammageing. Aiming to explore the additional non-tumourigenic consequences of Atrx deletion, we characterised an aged series of Atrx conditional disruption in β cells using the Pdx1 promoter. Homozygous mice (P.AtrxHOM) exhibited obesity, diabetes, glucose intolerance, and pancreatic adiposity at a higher extent than age- and sex-matched controls (P.AtrxWT).engAtrxConditional mouse modelEndocrine dysfunctionFatty pancreasPancreatic fatty replacementHyperglycaemiaHepatic stetosisInflammageingObesityPdx1-Crejournal article10.3390/cancers151130182072-6694