Rodrigues, LiaPaula, Arnaud Da CruzSoares, PaulaVinagre, João2024-05-202024-05-202024-03-22Rodrigues, L., Da Cruz Paula, A., Soares, P., & Vinagre, J. (2024). Unraveling the significance of DGCR8 and miRNAs in Thyroid Carcinoma. Cells, 13(7), Artigo 7. https://doi.org/10.3390/cells13070561http://hdl.handle.net/10400.22/25531MicroRNAs (miRNAs) act as negative regulators for protein-coding gene expression impacting cell proliferation, differentiation, and survival. These miRNAs are frequently dysregulated in cancer and constitute classes of blood-based biomarkers useful for cancer detection and prognosis definition. In thyroid cancer (TC), the miRNA biogenesis pathway plays a pivotal role in thyroid gland formation, ensuring proper follicle development and hormone production. Several alterations in the miRNA biogenesis genes are reported as a causality for miRNA dysregulation. Mutations in microprocessor component genes are linked to an increased risk of developing TC; in particular, a recurrent mutation affecting DGCR8, the E518K. In this review, we explore these novel findings and resume the current state-of-the-art in miRNAs in thyroid carcinomas.engmicroRNAs E518KThyroid cancerDGCR8E518Kjournal article10.3390/cells130705612073-4409