Vale, NunoCollins, Margaret S.Gut, JiriFerraz, RicardoRosenthal, Philip J.Cushion, Melanie T.Moreira, RuiGomes, Paula2022-05-092022-05-092008-01-15Vale, N., Collins, M. S., Gut, J., Ferraz, R., Rosenthal, P. J., Cushion, M. T., Moreira, R., & Gomes, P. (2008). Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. Bioorganic & Medicinal Chemistry Letters, 18(2), 485-488. https://doi.org/https://doi.org/10.1016/j.bmcl.2007.11.1050960-894Xhttp://hdl.handle.net/10400.22/20459A series of primaquine-derived imidazolidin-4-ones were screened for their in vitro activity against Pneumocystis carinii and Plasmodium falciparum W2 strain. Most compounds were active against P. carinii above 10 lg/mL and displayed slight to marked activity. The imidazolidin-4-ones most active against P. carinii were also those most active antiplasmodial agents, in the lM range. One of the tested imidazolidin-4-ones was slightly more active than the parent primaquine and may represent a lead com pound for the development of novel anti-P. carinii 8-aminoquinolines with increased stability and resistance to metabolic inactivation.engAIDSAntimalarialAntiplasmodialHIVInfectionMalariaPlasmodium falciparumPneumocystis cariniiPrimaqjournal article10.1016/j.bmcl.2007.11.1051464-3405