Gomes, AnaBessa, Lucinda J.Correia, PatríciaFernandes, IvaFerraz, RicardoGameiro, PaulaTeixeira, CátiaGomes, Paula2020-12-042020-12-042020Gomes, A., Bessa, L. J., Correia, P., Fernandes, I., Ferraz, R., Gameiro, P., Teixeira, C., & Gomes, P. (2020). “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability. International Journal of Molecular Sciences, 21(17), 6174. https://www.mdpi.com/1422-0067/21/17/6174http://hdl.handle.net/10400.22/16530A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.engAntibacterialAntibiofilmIonic liquidMultidrug resistancePeptideSkin infectionsTyrosinaseWound healingjournal article10.3390/ijms21176174