Costa, J.Oliveira, S.Oliveira, R.Prudêncio, CristinaFernandes, Rúben2024-10-232024-10-232015-10Costa, Oliveira, S., Oliveira, R., Prudencio, C., & Fernandes, R. (2015). The role of MTHFR polymorphisms in breast cancer risk– A metaanalysis. 7º Simpósio em Metabolismo da Faculdade de Medicina da Universidade do Porto, Revista Portuguesa de Diabetes. 2015; 10 (4):, 186–187http://hdl.handle.net/10400.22/26259Breast cancer incidence has been increasing by more than one million new cases every year and is a primary cause of cancer death among women worldwide. Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and as a regulator of DNA methylation, synthesis, and repair. MTHFR gene is polymorphic at nucleotides 677 (C®T) and 1298 (A®C), resulting in allozymes with decreased activity. Several studies have pointed to association between the MTHFR C677T polymorphism and breast cancer risk.engMTHFR polymorphismsBreast cancer riskconference object