Ferreira, SaraAbrantes, Ana MargaridaLaranjo, MafaldaMetello, Luís F.Casalta-Lopes, JoãoDormehl, IreneBotelho, Maria Filomena2015-07-092015-07-092014http://hdl.handle.net/10400.22/6429Introduction: The polymer PEI-MP (polyethyleneiminomethyl phosphonic acid) might be labelled with 99mTc. It was initially synthesized for palliative therapy of bone metastases after convenient radiolabelling, however in biodistribution studies performed with different PEI-MP/radionuclides, was obvious that the bladder wall was a target organ [1-3], demonstrating a certain selectivity to bladder cells, and so, to bladder cancer cells. The aim of this study was to evaluate the efficacy of 99mTc-PEI-MP for diagnosis of bladder carcinoma, evaluating in vitro and in vivo the biokinetics and biodistribution of 99mTc-PEI-MPengother