Alexandrino, Ana SilvaSantos, RitaMelo, CristinaMesquita Bastos, JoséPostiaux, Guy2023-03-242023-03-242017-08-28Alexandrino, A.S., Santos, R., Melo, C. et al. Caregivers’ education vs rhinopharyngeal clearance in children with upper respiratory infections: impact on children’s health outcomes. Eur J Pediatr 176, 1375–1383 (2017). https://doi.org/10.1007/s00431-017-3003-z0340-6199http://hdl.handle.net/10400.22/22581Upper Respiratory Tract Infections (URTI) are very common in children having no effective pharmacological treatment. This study aimed to compare the effect of caregivers’ health education regarding children’s respiratory infections and the effect of a rhinopharyngeal clearance protocol in children with URTI. A factorial trial was conducted in 138 children up to 3 years, attending day-care centres. Children were distributed into four groups: control group (CG) (n = 38); education group (EG) (n = 34); intervention group (IG) (n = 35); and education and intervention group (E + IG) (n = 31). A Diary of Records was kept by caregivers during 1 month. There were significant differences between groups concerning: Lower Respiratory Tract Infections (CG = 29.4%; EG = 10.7%; IG = 3.8%; E + IG = 0.0%; p = 0.014); acute otitis media (CG = 32.4%; EG = 7.1%; IG = 11.5%; E + IG = 7.7%; p = 0.014); medical consultations (CG = 70.6%; EG = 42.9%; IG = 38.5%; E + IG = 30.8%; p = 0.021); antibiotics (CG = 44.1%; EG = 7.1%; IG = 23.1%; E + IG = 15.4%; p = 0.006); days missed from day-care (CG = 55 days; EG = 22 days; IG = 14 days; E + IG = 6 days; p = 0.020); days missed from employment (CG = 31 days; EG = 20 days; IG = 5 days; E + IG = 1 day; p = 0.021); and nasal clearance techniques (CG = 41.4%; EG = 78.6%; IG = 57.7%; E + IG = 84.6%; p = 0.011).engHealth educationHealth impact assessmentRespiratory disordersChildrenNasal irrigationRhinopharyngeal clearancejournal article10.1007/s00431-017-3003-z1432-1076