Costa, J.Oliveira, R.Prudêncio, CristinaFernandes, Rúben2023-10-252023-10-252016-12Costa, J., Oliveira, R., Prudêncio, C., & Fernandes, R. (2016). Is the MTHFR C677T polymorphism associated with obesity risk? – A meta-analysis. 8o Simpósio em Metabolismo da Faculdade de Medicina da Universidade do Porto, 11 (4) Revista Portuguesa de Diabetes, 181.1646-3994http://hdl.handle.net/10400.22/23777Overweight and obesity are a major worldwide health problem and its incidence is increasing every year. Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and as a regulator of DNA methylation, synthesis, and repair. MTHFR gene is polymorphic at nucleotides 677 (C→T) and 1298 (A→C). MTHFR C677T polymorphism results in alloenzymes with decreased activity and several studies have pointed to association between the MTHFR C677T polymorphism and overweight/obesity risk.engMTHFRC677TPolymorphismObesityRiskconference object