Santos, MarleneCarvalho, SerafimLima, LuísMota-Pereira, JorgePimentel, PauloMaia, DulceCorreia, DianaGomes, SofiaCruz, AgostinhoMedeiros, Rui2022-02-172022-02-172015-11Oliveira, A. I., Pinho, C., Fonte, P., Sarmento, B., & Dias, A. C. (2015). Development of polymeric nanoparticles containing neuroprotective compounds of Hypericum perforatum. In R. A. Silva, P. Baylina, F. Q. Vieira, C. Barrias, M. Rubim, T. Coelho, C. Prudêncio, & Â. Jesus (Eds.), II Congresso Internacional da Saúde Gaia Porto: Livro de Resumos (pp. 15-16). Escola Superior de Tecnologia da Saúde do Instituto Politécnico do Porto.978-989-20-6340-9http://hdl.handle.net/10400.22/19991Major Depressive Disorder (MDD) is a highly prevalent chronic psychiatric condition with significant morbidity. Despite several antidepressants drugs (AD) available, a wide fraction of patients fail to respond, present relapse or display treatment resistant depression (TRD). Pharmacogenomics could help identify patients at risk of relapse or TRD and possibly have a direct impact on personalizing therapy. Additionally, recent studies suggested that immune activation and cytokines may be involved in depression, and its normalization occurs after antidepressant treatment. The proinflammatory cytokines interleukin-18 (IL-18) and IL-6 are less reported in depression, but considered to be relevant since they have been found to be increased in patients with depression.engconference object