Lemos, JoanaNeuparth, T.Trigo, M.Costa, PedroVieira, DomingosCunha, L.Ponte, F.Costa, P. S.Metello, LuísCarvalho, A. P.2019-06-272019-06-272016http://hdl.handle.net/10400.22/14139This study investigated to what extent a single exposure to low doses of ionizing radiation can induce genotoxic damage in irradiated adult zebrafish (Danio rerio) and its non-irradiated F1 progeny. Four groups of adult zebrafish were irradiated with a single dose of X-rays at 0 (control), 100, 500 and 1000 mGy, respectively, and couples of each group were allowed to reproduce following irradiation. Blood of parental fish and whole-body offspring were analysed by the comet assay for detection of DNA damage. The level of DNA damage in irradiated parental fish increased in a radiation dose-dependent manner at day 1 post-irradiation, but returned to the control level thereafter. The level of DNA damage in the progeny was directly correlated with the parental irradiation dose. Results highlight the genotoxic risk of a single exposure to low-dose ionizing radiation in irradiated individuals and also in its non-irradiated progeny.engAnimalsGenotoxicityDNA DamageGamma RaysZebrafishRadiation ExposureRadiation, Ionizingjournal article10.1007/s00128-016-2006-1