Vojtek, MartinPinto, EdgarGonçalves-Monteiro, SaloméAlmeida, AgostinhoMarques, M. P. M.Mota-File, HélderFerreira, Isabel M. P. L. V. O.Diniz, Carmen2020-12-042021-08-212020-08-21Vojtek, M., Pinto, E., Gonçalves-Monteiro, S., Almeida, A., Marques, M. P. M., Mota-Filipe, H., Ferreira, I. M. P. L. V. O., & Diniz, C. (2020). Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies [10.1039/D0AY01328E]. Analytical Methods, 12(39), 4806-4812. https://doi.org/10.1039/D0AY01328Ehttp://hdl.handle.net/10400.22/16535Palladium-(Pd)-based drugs are emerging as alternatives to platinum (Pt) anticancer chemotherapeutics, which increases the need for efficient and suitable procedures of Pd analysis in reduced amounts of pre-clinical animal samples. Herein, an ICP-MS (inductively coupled plasma-mass spectrometry) method was developed and validated for simple and fast analysis of Pd/Pt-based drugs in 11 distinct biological matrices (adipose tissue, muscle, liver, kidney, spleen, testis, heart, lungs, brain, blood and serum).engICP-MSPharmacokineticAnimalPalladiumjournal article10.1039/D0AY01328E