Amorim, ManuelaSilva, Ana IsabelAlves, Cecília JulianaMonteiro, Pedro R.Magalhães, AnaSummavielle, Teresa2025-07-082025-07-082019-10Amorim, M., Silva, A. I., Alves, C. J., Monteiro, P. R., Magalhães, A., & Summavielle, T. (2019). Peripheral metabolism in rat with olanzapine subchronic treatment supplemented with acetyl-L carnitine. 11o Simpósio de Metabolismo da Faculdade de Medicina da Universidade do Porto - Revista Portuguesa de Diabetes, 14(4). http://www.revportdiabetes.com/wp-content/uploads/2020/02/RPD-DEZ-2019-Revista-Nacional-págs-164-175.pdfhttp://hdl.handle.net/10400.22/30211Olanzapine (Olz) have been reported to promote higher risk for metabolic side-effects, such as obesity, dyslipidemia, and diabetes. Moreover/On the other hand, acetyl-L-carnitine (ALC) has been reported to improve homeostasis. This study aims to explore if ALC could improve metabolic homeostasis due to Olz effects on a rodent model. We investigated the effects of subchronic administration of Olz and with the addition of ALC on body weight gain and glucose metabolism in Wistar rats. Mid-term Olz exposure in rats significantly increases blood glucose levels in fasting and after the overload of glucose compared to the sali-ne-treated group (p<0.05). However, in rats mid-term treated with olanzapine plus acetyl-L-carnitine had no significant differences in fasting blood glucose levels compared to the saline-treated group. The findings suggest that ALC added to Olz treatment appeared to be effective to improve glucose metabolism during olanzapine subchronic treatment.engOlanzapineAcetyl-L-carnitineGlucose homeostasisLocomotor activityconference poster