Tavares-Silva, EdgarFerreira, SaraAbrantes, Ana MargaridaBrito, AnaLaranjo, MafaldaMetello, Luís F.Zeevart, JanLouw, WernerDormehl, IreneBotelho, Maria Filomena2015-07-092015-07-092013http://hdl.handle.net/10400.22/6460Introduction: The polymer PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) was initially synthesized for palliative therapy of bone metastases after convenient radiolabelling. However, in biodistribution studies performed with this polymer radiolabelled with different radionuclides, was obvious a higher uptake by the bladder wall, that might demonstrate a certain selectivity to bladder cells, and so, to bladder cancer cells. The aim of this study was to evaluate the efficacy of PEI-MP radiolabeled with 99mTc for imaging diagnosis and follow up of bladder cancer.engother