Ferreira, SaraAbrantes, Ana MargaridaMetello, Luís F.Zeevart, JanLouw, WernerDormehl, Irene D.Botelho, Maria Filomena2015-01-302015-01-302010-10-15http://hdl.handle.net/10400.22/5544Introduction: 188Re is a promising radionuclide for metabolic therapy because of the emission of high energy beta-particles. The development of watersoluble bone-seeking polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate-groups) that might be labeled with 188Re are recent approaches, with a strong potential for bone cancer treatment. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP, as therapeutic agent for osteosarcoma, through in vitro and in vivo models.engconference object