Garrido, E. ManuelaGarrido, JorgeBorges, F.Delerue-Matos, Cristina2013-11-252013-11-252003http://hdl.handle.net/10400.22/2948A square-wave voltammetric (SWV) method and a flow injection analysis system with amperometric detection were developed for the determination of tramadol hydrochloride. The SWV method enables the determination of tramadol over the concentration range of 15-75 µM with a detection limit of 2.2 µM. Tramadol could be determined in concentrations between 9 and 50 µM at a sampling rate of 90 h-1, with a detection limit of 1.7 µM using the flow injection system. The electrochemical methods developed were successfully applied to the determination of tramadol in pharmaceutical dosage forms, without any pre-treatment of the samples. Recovery trials were performed to assess the accuracy of the results; the values were between 97 and 102% for both methods.engTramadolSquare-wave voltammetryFIAElectrochemical detectionjournal article10.1016/S0731-7085(03)00199-7