Machado, PatríciaTeixeira, DulceVieira, MónicaPrudêncio, Cristina2024-06-142024-06-142018-05-18Machado, P., Teixeira, D., Vieira, M., & Prudêncio, C. (2018). Development of a method based on HPLC-DAD for the detection and quantification of glutamate and gammaaminobutyric acid. Book of abstracts of the III Encontro de Biotecnologia Medicinal/ I Iberian Congress on Medicinal Biotechnology, 25. https://paginas.ess.ipp.pt/ebtm/2018/3EBtM_BookOfAbstracts.pdf978-989-20-8533-3http://hdl.handle.net/10400.22/25660With the increasing incidence of neurodegenerative diseases, the need arose to study several molecules that may be useful to the study of new therapies and to treat the symptoms that come with these diseases, as is the case of depression. GABA and glutamate have a very important role in the homeostasis of the organism and molecules of interest and potential from the point of view of diagnosis are revealed. HPLC is a method that allows the detection and quantification of various analytes in different biological matrices, allowing rapid results with high precision, sensitivity and specificity.engNeurodegenerative diseasesDepressionGABAGlutamateHPLC-DADconference object