Mancini, SimonaNardo, LucaGregori, MariaRibeiro, InêsMantegazza, FrancescoDelerue-Matos, CristinaMasserini, MassimoGrosso, Clara2019-10-072019-10-072018-010944-7113http://hdl.handle.net/10400.22/14710Multi-target drugs have gained significant recognition for the treatment of multifactorial diseases such as depression. Under a screening study of multi-potent medicinal plants with claimed antidepressant-like activity, the phenolic-rich Annona muricata aqueous extract (AE) emerged as a moderate monoamine oxidase A (hMAO-A) inhibitor and a strong hydrogen peroxide (H2O2) scavenger.engAnnonaAntioxidantsBlood-Brain BarrierDrug CarriersEndothelial CellsFree Radical ScavengersHumansHydrogen PeroxideLiposomesMonoamine Oxidase InhibitorsNanostructuresPhenolsPlant Extractsjournal article10.1016/j.phymed.2018.03.053